NMN ua dab tsi rau lub cev?

Los ntawm qhov siab -kev lag luam neeg siv khoom kawg mus rau kev txiav- cov chaw soj ntsuam kev tshawb fawb,NMNyog hailed raws li lub hnub qub molecule nrog lub peev xwm rov qab aging. Txawm li cas los xij, txhawm rau tshem tawm cov pos huab ntawm kev lag luam, raws li cov kws tshaj lij kev lag luam thiab cov kws tshawb fawb, peb yuav tsum rov qab mus rau lub hauv paus ntawm kev tshawb fawb thiab tshawb nrhiav cov lus nug tseem ceeb: dab tsi ua raws nraim.NMNua rau tib neeg lub cev?

Kom nkag siab txog lub luag haujlwm ntawmNMN, ib qho yuav tsum xub paub txog NAD + (nicotinamide adenine dinucleotide).

NAD + yog ib qho tseem ceeb ntawm coenzyme nyob rau hauv tib neeg lub cev, tam sim no nyob rau hauv txhua lub cell nyob thiab koom nrog ntau pua ntawm cov haujlwm tseem ceeb ntawm lub cev. Nws tsis yog tsuas yog lub hauv paus ntawm cellular zog metabolism (xws li lub voj voog tricarboxylic acid thiab oxidative phosphorylation), tab sis kuj yog ib qho tseem ceeb "roj" rau kev tswj cov txheej txheem ntawm lub neej, suav nrog DNA kho, cell signaling, thiab gene qhia kev cai. Ntau qhov kev tshawb fawb tseem ceeb tau lees paub tias nrog lub hnub nyoog, qib ntawm NAD + hauv tib neeg lub cev txo qis, uas yog suav tias yog ib qho tseem ceeb ntawm kev tsav tsheb uas ua rau kev laus thiab cuam tshuam txog kev ua haujlwm tsis zoo, xws li cov kab mob metabolic thiab muaj kev pheej hmoo ntawm cov kab mob neurodegenerative.

Txoj kev xav thaum kawg yuav tsum tau sim los ntawm kev xyaum. Hmoov zoo, txij xyoo 2020 txog 2024, ntau tus neeg siab -kev sim tshuaj zoo tib neeg tau tshwm sim thoob ntiaj teb, muab cov ntaub ntawv tseem ceeb rau peb los ntsuas qhov ua tau zoo ntawmNMN.

Kev ntsuam xyuas ntawm ib qho ntxiv pib nrog kev nyab xeeb. Ntau qhov kev tshawb fawb soj ntsuam tau pom tsis tu ncua tias NMN nthuav tawm kev nyab xeeb zoo thiab kev zam rau tib neeg lub cev.

• Cov ntaub ntawv pov thawj: Piv txwv li, ib txoj kev tshawb fawb luam tawm nyob rau hauv Endocrine Journal xyoo 2020 los ntawm Keio University Tsev Kawm Ntawv ntawm Tshuaj hauv Nyij Pooj tau ua 12 lub lis piam, ib qho kev sim ntawm 100mg, 250mg, thiab 500mg NMN hauv cov txiv neej noj qab haus huv. Cov txiaj ntsig tau pom tias cov cim tseem ceeb ntawm lub cev xws li lub plawv dhia, ntshav siab, thiab lub cev kub tsis tau qhia qhov hloov pauv loj, thiab tsis muaj cov xwm txheej tsis zoo cuam tshuam txog NMN tau tshaj tawm.

Zuag qhia tag nrho, cov pov thawj kev kho mob uas twb muaj lawm feem ntau txhawb tias kev noj tshuaj ntxiv txhua hnub txog li 1250 milligrams ntawm NMN muaj kev nyab xeeb. Txawm hais tias cov kev tshawb fawb tau pom tias muaj kev nce me ntsis hauv cov ntawv ceeb toom ntawm cov xwm txheej tsis zoo (xws li mob plab hnyuv) ntawm koob tshuaj 1000mg / hnub lossis siab dua, tag nrho, tsis muaj kev phom sij loj heev tau raug txheeb xyuas.

NMN puas tuaj yeem txhim kho tib neeg NAD + qib? Cov lus teb yog qhov tseeb, thiab tam sim no yog qhov kev txiav txim siab tshaj plaws raws li cov pov thawj kho mob.

• Cov pov thawj 1: Ib qho loj randomised, multicenter, ob - qhov muag tsis pom kev, placebo- tswj kev soj ntsuam soj ntsuam luam tawm nyob rau hauv daim ntawv tso cai gerontology phau ntawv journal Geroscience hauv 2023 muab cov pov thawj muaj zog rau peb. Txoj kev tshawb no coj los ntawm Yi L li al. thiab suav nrog 80 tus neeg noj qab haus huv nruab nrab- cov neeg laus uas tau txais 300mg, 600mg, thiab 900mg ntawm NMN tshuaj noj txhua hnub. Cov txiaj ntsig tau pom tias tom qab 30 thiab 60 hnub ntawm kev ntxiv, tag nrho cov ntshav NAD + cov ntsiab lus ntawm txhua pawg NMN tau pom qhov nce ntxiv (p Tsawg dua lossis sib npaug rau 0.001) piv rau pawg hauv paus thiab cov placebo, thiab qhov kev txhim kho no tau nthuav tawm cov koob meej meej- nyob ntawm tus qauv.
• Cov ntaub ntawv pov thawj 2: Lwm txoj kev tshawb fawb tau muab cov txiaj ntsig tshwj xeeb: nrog lub hauv paus nruab nrab ntawm tag nrho cov ntshav NAD + qib ntawm 23.8 ± 5.5 μM, cov kev kawm uas ntxiv nrog 1000mg NMN txhua hnub muaj lawv cov NAD + qib nce mus rau 58.8 ± 21.1 μM, ntau dua ob npaug.

Cov ntaub ntawv no irrefutably lees paub qhov ua tau zoo ntawm qhov ncaujNMNraws li NAD + cov tswv yim ntxiv.

Thaum kawg ntawm 2025, lub zej zog scientific teb rau lo lus nug ntawm "dab tsi yog qhov cuam tshuam ntawmNMNRaws li kev nyab xeeb thiab muaj txiaj ntsig ua ntej ntawm NAD +, NMN lub peev xwm los txhim kho tib neeg NAD + qib tau raug kuaj xyuas tag nrho.Rau lub hauv paus no, nws pom muaj peev xwm txhim kho cov metabolism hauv kev noj qab haus huv, txhim kho lub cev muaj zog, thiab txhim kho kev pw tsaug zog hauv cov neeg tshwj xeeb. nws ntev dua -lub sij hawm los tiv thaiv-aging teebmeem,NMNyog undoubtedly ib qho ntawm cov kev ua tau zoo tshaj plaws nyob rau hauv lub teb ntawm kev laus science translation nyob rau hauv xyoo tas los.

Yog xav paub ntxiv txogNMN, txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn; +86-138-0919-0407)

Kev siv

[1] Tomas Schmauck-Medina, Adrian Molière et al. "Cov ntsiab lus tshiab ntawm kev laus: 2022 Copenhagen aging lub rooj sib tham xaus." Aging (Albany, NY) (2022). [2022-08-29]

[2]Sajid ur Rahman, Abdul Qadeer et al. "Lub luag haujlwm thiab peev txheej ntawm Nicotinamide Mononucleotide hauv Kev Laus." Kev laus thiab kab mob (2023).

[2023-07-27]

[3]NMN "Nicotinamide Mononucleotide" Activates Intracellular Zog thiab mus rau kev tiv thaiv thiab txhim kho kev laus. Satoshi Kawakami et al. [2022-05-20]

[4] Txhim kho lub cev ua haujlwm tsis zoo hauv cov neeg mob noj Nicotinamide Mononucleotide (NMN): Kev Ntsuam Xyuas Txheej Txheem ntawm Randomized Controlled Trials. Jimmy Wen et al. [2024-08-01]

[5] Kev Nyab Xeeb thiab Kev Tiv Thaiv Kev Tiv Thaiv ntawm Nicotinamide Mononucleotide hauv Tib Neeg Kev Kho Mob: Kev Hloov Kho. Qin Song et al. [2023]