Puas yog txiv apples (apple polyphenol) tiv thaiv -mob raum?

Nyob rau hauv xyoo tas los no, nrog kev loj hlob sai ntawm cov nroj tsuag extract kev lag luam thiab kev ua kom tob zuj zus ntawm kev tshawb fawb txog kev ua neej, cov tshuaj tiv thaiv -cov khoom ntawmpolyphenols ntawm txiv applesthiab lawv cov kev tiv thaiv ntawm cov kabmob tshwj xeeb, tshwj xeeb tshaj yog rau lub raum, tau nyiam cov kws tshawb fawb thoob ntiaj teb kev saib xyuas.

Kua Polyphenols (AP)tsis yog ib qho kev sib xyaw ua ke, tab sis lub ntsiab lus sib sau ua ke rau cov tshuaj polyphenolic muaj nyob hauv cov txiv apples. Cov tshuaj no feem ntau yog muab faib rau hauv tev thiab nqaij ntawm txiv apples, nrog rau cov tev muaj ntau dua li cov nqaij. Nws cov khoom tseem ceeb suav nrog

• flavonols (xws li quercetin thiab nws cov glycosides)
• catechins (xws li epicatechin thiab epigallocatechin)
• anthocyanins (feem ntau pom nyob rau hauv liab- txiv apples tawv)
• phenolic acids (xws li chlorogenic acid)
• dihydrochalcones (xws li puerarin).

Nws yog synergistic nyhuv ntawm cov sib txawv tebchaw uas endowspolyphenols ntawm txiv applesnrog ntau yam kev ua lom lom.

Hauv kev lag luam cog extract,polyphenols ntawm txiv applesfeem ntau yog npaj los ntawm cov txiv apples tshiab los ntawm cov txheej txheem extraction thiab purification, tsim cov khoom lag luam extract. Cov khoom no tau siv dav hauv cov khoom noj khoom haus, cov khoom noj qab haus huv, thiab cov tshuaj pleev ib ce vim lawv cov ntsiab lus muaj txiaj ntsig zoo thiab kev ua haujlwm ruaj khov.

Kev mob yog lub cev tiv thaiv ib txwm muaj rau kev raug mob lossis kis kab mob, tab sis mob ntev, tsis tswj tau qhov mob yog qhov tshwm sim ntawm ntau yam kab mob, suav nrog kab mob raum, kab mob plawv, thiab ntshav qab zib. Ntau tus xovtooj ntawm tes thiab tsiaj tshawb fawb tau lees paub tiaspolyphenols ntawm txiv applesmuaj qhov tseem ceeb los tiv thaiv-kev ua ub no, thiab lawv cov txheej txheem ntawm kev ua haujlwm yog qhov nyuaj thiab ntau- lub hom phiaj, feem ntau tsom rau cov hauv qab no:

Lub ntsiab lus nuclear kappa B (NF-κB) qhia txoj hauv kev yog lub hauv paus tseem ceeb rau kev tswj cov lus teb inflammatory. Nyob rau hauv lub xeev inflammatory, NF-κB yog qhib thiab nkag mus rau hauv lub nucleus los pib transcription ntawm ntau yam pro-inflammatory cytokine noob, xws li qog necrosis factor- (TNF- ), interleukin{11}}1 (IL-1), thiab interleukin-6 (IL-6). Ntau qhov kev tshawb fawb tau pom tias cov kua polyphenols tuaj yeem cuam tshuam kev ua haujlwm ntawm NF-κB txoj hauv kev, yog li txo qis kev tsim khoom thiab tso tawm cov tseem ceeb pro-inflammatory cytokines los ntawm qhov chaw.

Cyclooxygenase-2 (COX-2) thiab inducible nitric oxide synthase (iNOS) yog ob lub enzymes tseem ceeb hauv cov txheej txheem inflammatory. COX-2 catalyzes cov synthesis ntawm prostaglandin E2 (PGE2), uas yog ib qho tseem ceeb nruab nrab ntawm kev mob, kub taub hau, thiab o. INOS ua rau ntau cov nitric oxide (NO), ua rau oxidative kev nyuaj siab thiab cov ntaub so ntswg puas.Kua polyphenolstau pom tias txo qis cov kev qhia thiab kev ua haujlwm ntawm COX-2 thiab iNOS, yog li ncaj qha txo qis kev tsim cov kab mob sib kis thiab txo cov tsos mob ntawm tus mob.

Kua polyphenolstsis tsuas yog muaj zog antioxidants uas tuaj yeem tshem tawm cov dawb radicals ncaj qha, tab sis qhov tseem ceeb tshaj, lawv tuaj yeem qhib "tus thawj coj- hauv- tus thawj tswj hwm" txoj hauv kev antioxidant hauv hlwb - Nrf2 (nuclear factor E2 ntsig txog 2) qhia txoj hauv kev. Activated Nrf2 txhawb kev nthuav qhia ntawm cov enzymes qis qis qis (xws li heme oxygenase-1, HMOX1), yog li txhim kho lub cell tus kheej lub peev xwm tiv thaiv antioxidant thiab indirectly inhibiting inflammatory teb induced los ntawm oxidative kev nyuaj siab.

Raws li cov pov thawj scientific uas twb muaj lawm, peb tuaj yeem kos cov lus xaus hauv qab no:
Kua polyphenolsnthuav tawm muaj zog los tiv thaiv- mob tshwm sim hauv vitro thiab tsiaj qauv los ntawm inhibiting NF-κB txoj hauv kev, tswj kev mob o-txog enzymes xws li COX-2 thiab iNOS, thiab ua kom Nrf2 antioxidant txoj hauv kev los ntawm ntau lub tshuab. Rau cov nroj tsuag extract kev lag luam,polyphenols ntawm txiv applesyog undoubtedly ib lub hnub qub khoom nrog zoo kev ua lag luam muaj peev xwm. Nrog rau qhov kev thov nce ntxiv ntawm cov neeg siv khoom rau cov khoom ntuj thiab noj qab haus huv, nrog rau kev ua kom tob zuj zus ntawm kev tshawb fawb tshawb fawb, daim ntawv thov ntawmpolyphenols ntawm txiv applesnyob rau hauv cov khoom noj khoom haus thiab cov khoom noj khoom haus yuav ua kom dav dua. Cov lus teb inflammatory hauv zos thiab tiv thaiv -fibrosis muaj feem cuam tshuam.

Yog xav paub ntxiv txogpolyphenols ntawm txiv apples, txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn; +86-138-0919-0407)

Kev siv

[1] Kev nce qib hauv lub ntiaj teb xav tsis thoob ntawm Phytochemicals: Xeev- ntawm --Art rau Antioxidants. Antonella D'Anneo et al. [2023]

[2] Lub Hom Phiaj Nrf2 thiab NF-κB Txoj hauv kev taw qhia txoj hauv kev mob mob: Lub luag haujlwm ntawm Polyphenols los ntawm Thinned Apples. Livia Interdonato et al. [2023-07-13]

[3] Zhang, M. Zeng et al. "Puas yog ib lub txiv apples ib hnub kom tshem tau cov kab mob? Cov pov thawj thiab cov txheej txheem ntawm kev ua." Food Science & Nutrition (2023). [2023-06-20]

[4] T. Yue, Xuelian Bai et al. "Fractionation and anti-inflammatory teebmeem ntawm polyphenol-enriched extracts los ntawm apple pomace." Bangladesh Journal of Pharmacology (2012). [2012-03-28]