Cov txiv apples puas pab rau daim tawv nqaij laus?

Apples ua lub luag haujlwm tseem ceeb hauv kev saib xyuas tib neeg kev noj qab haus huv. Txawm li cas los xij, nrog kev loj hlob sai ntawmcog extractthev naus laus zis niaj hnub no, peb pab tsis tau tab sis nug: puas muaj kev noj qab haus huv khawv koob ntawm txiv apples kuj tseem txuas ntxiv mus rau ib qho ntawm peb qhov kev txhawj xeeb tshaj plaws - tawv nqaij tiv thaiv - laus?

Kev laus ntawm daim tawv nqaij yog cov txheej txheem lom neeg uas tau tsav los ntawm ob qho tib si endogenous yam (xws li noob caj noob ces thiab hormonal hloov) thiab exogenous yam (xws li hluav taws xob ultraviolet thiab ib puag ncig muaj kuab paug). Nws cov kab mob tseem ceeb muaj xws li oxidative kev nyuaj siab puas tsuaj, collagen poob thiab degradation, thiab impaired daim tawv nqaij barrier muaj nuj nqi. Kev tshawb fawb tau pom tias cov txiv apples muaj ntau yam khoom xyaw bioactive, uas ua raws li kev sib koom ua ke "lub zog" uas tuaj yeem cuam tshuam rau cov txheej txheem ntawm daim tawv nqaij los ntawm ntau lub hom phiaj.

Kua polyphenolsyog cov tseem ceeb tshaj plaws antioxidant tebchaw nyob rau hauv apples, thiab lawv yog tshwj xeeb tshaj yog nplua nuj nyob rau hauv tev. Nws tsis yog ib qho kev sib xyaw ua ke, tab sis ib tsev neeg polyphenol suav nrog chlorogenic acid, catechins, epicatechins, quercetin glycosides, thiab lwm yam. Nws cov txheej txheem tiv thaiv - kev laus yog qhov tseem ceeb hauv cov hauv qab no:

• Muaj zog dawb radical scavenging peev xwm: Dawb radicals yog "culprits" uas ua rau cell puas thiab laus.Kua polyphenolstuaj yeem cuam tshuam cov kab mob oxygen reactive (ROS) los ntawm kev muab cov khoom siv hluav taws xob, tshem tawm cov dawb radicals zoo thiab txo qhov kev puas tsuaj ntawm oxidative kev nyuaj siab rau ntawm daim tawv nqaij. Ntau qhov kev tshawb fawb tau lees paub tiastxiv apples polyphenolstxo kev tsim cov dawb radicals los ntawm inhibiting cov haujlwm ntawm tyrosinase thiab catalase.
• Kev tiv thaiv thiab kev txhawb nqa ntawm collagen: Kev poob thiab degradation ntawm collagen yog qhov ncaj qha ua rau wrinkles thiab sagging ntawm daim tawv nqaij. Ntawm ib sab, cov kev tshawb fawb tau pom tiastxiv apples polyphenolstuaj yeem tiv thaiv cov qauv collagen thiab elastin uas twb muaj lawm los ntawm kev tswj hwm collagen synthesis thiab inhibiting elastase kev ua haujlwm. Ntawm qhov tod tes,polyphenolsHauv cov txiv apples tsis paub qab hau tuaj yeem cuam tshuam qhov kev qhia ntawm matrix metalloproteinase-1, thaum txhawb kev tsim cov hom I procollagen (precursor ntawm collagen), yog li tswj cov qauv hluas ntawm daim tawv nqaij hauv ob qho tib si "qhib" thiab "throttling" yam.

Kua txiv kuj muaj ntau vitamin C. Raws li ib tug classic antioxidant thiab kev tu tawv nqaij cov khoom, lub mechanism ntawm kev txiav txim ntawm vitamin C nyob rau hauv anti- laus ntawm daim tawv nqaij tau lug paub tseeb. Vitamin C yog ib qho tseem ceeb cofactor rau prolyl hydroxylase thiab lysyl hydroxylase, ob qho tib si yog qhov tseem ceeb hauv kev tsim cov qauv helix ruaj khov nyob rau hauv collagen molecules. Qhov tsis muaj vitamin C yuav cuam tshuam ncaj qha rau collagen synthesis. Yog li, cov vitamin C muab los ntawm cov txiv apples muab kev txhawb nqa biochemical tsim nyog rau kev tswj cov tawv nqaij firmness thiab elasticity.

Nyob rau hauv xyoo tas los no, cog qia cell thiab extracellular vesicle thev naus laus zis tau qhib qhov chaw tshiab rau kev tiv thaiv kev laus - kev tshawb fawb.

Kua qia cell extract: Ntau cov kev tshawb fawb tau pom tias cov khoom tu tawv nqaij uas muaj cov kua qia cell extract muaj cov tshuaj lom neeg ua haujlwm rau cov cim ntawm daim tawv nqaij laus. Ib lub qab zib uas muaj kua txiv hmab txiv ntoo extract thiab ascorbic acid tuaj yeem txo cov cim ntawm kev laus pom ntawm lub ntsej muag. Cov txheej txheem hauv qab no tuaj yeem cuam tshuam nrog cov txheej txheem epigenetic thiab cov metabolites nplua nuj nyob rau hauv qia cell extracts, uas tuaj yeem tiv thaiv tib neeg cov tawv nqaij qia hlwb thiab ncua lawv cov laus.

Lub zog ntawm theoretical mechanisms thaum kawg yuav tsum muaj kev lees paub los ntawm kev siv tshuaj kho mob. Hmoov zoo, kev tshawb fawb pov thawj ntawm kev txhim kho ntawm daim tawv nqaij laus los ntawmtxiv apple extracttab tom muaj ntau zuj zus.

Kev tshuaj xyuas cov kev tshawb fawb tau pom tias cov kua txiv derivatives tau pom tias muaj txiaj ntsig zoo hauv kev txhim kho cov tawv nqaij laus, ob qho tib si ntawm qhov ncauj thiab qhov ncauj, pom tau tias ua kom tawv nqaij noo noo, txhim kho elasticity, ua kom tawv nqaij ceev, thiab txo qis wrinkles.

• Kev txheeb xyuas kev ua tau zoo sab nraud: Ib qho ob - qhov muag tsis pom kev, cov placebo- tswj kev soj ntsuam kev tshawb fawb pom tias kev siv cov tshuaj pleev ib ce uas muaj cov txiv apples qus extract tau txhim kho daim tawv nqaij muaj peev xwm hluav taws xob (qhov taw qhia ntawm stratum corneum barrier muaj nuj nqi thiab dej), qhia tias cov khoom siv moisturizing thiab barrier.
• Cov txiaj ntsig ntawm qhov ncauj ntxiv: Cov ntaub ntawv kho mob qhia tau tias tom qab plaub lub lis piam sib law liag ntawm kev ntxiv cov kua txiv hmab txiv ntoo, cov ntsiab lus ntawm cov tawv nqaij noo noo tau nce 13.4% thiab cov kab zoo kuj tau txhim kho. Qhov no qhia tau hais tias kev ua tau zoo ntawmtxiv apple extracttuaj yeem ua tiav los ntawm kev tswj hwm qhov ncauj thiab kev cog qoob loo sab nraud.
• Cell-level validation: Kev tshawb fawb tau delved tob rau hauv cell theem thiab pom tiastxiv apple extracttuaj yeem ua kom zoo dua cov metabolism ntawm cov laus fibroblasts, rov ua haujlwm ntawm tes, uas piav qhia txog lub hauv paus ntawm nws cov khoom tiv thaiv - laus. Ntxiv rau,txiv apple extracttuaj yeem txo qhov kev puas tsuaj ntawm tes thiab DNA puas tsuaj los ntawm ultraviolet B (UVB) hluav taws xob, ua kom pom qhov zoo tshaj plaws photoprotective peev xwm.

Yog xav paub ntxiv txogtxiv apples polyphenols, txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn; +86-138-0919-0407)

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