Phloretin, ib tug natural dihydrochalcone compound, tau txais kev saib xyuas nyob rau hauv cov nroj tsuag extract kev lag luam nyob rau hauv lub xyoo tsis ntev los no vim nws cov tseem ceeb antioxidant, tiv thaiv -inflammatory, thiab daim tawv nqaij - whitening zog.
1, Ntuj cog Sources thiab cov ntsiab lus yam ntxwv ntawm Phloretin
Raws li ntau txoj kev tshawb fawb pov thawj,phloretinFeem ntau yog concentrated nyob rau hauv Rosaceae nroj tsuag, nrog txiv apples (Malus domestica) yog qhov tseem ceeb tshaj plaws lom neeg. Ib txoj kev tshawb fawb 2022 luam tawm hauvKhoom noj khoom haus Chemistryqhia tias tag nrho cov ntsiab lus ntawm phloretin thiab nws glycoside phloridzin nyob rau hauv cov kua tev tuaj yeem ncav cuag li 5.59 mg rau 100 g ntawm qhov hnyav, nrog rau cov laus tev muaj 3-5 npaug ntau dua cov pulp.[1]Nws yog ib qho tsim nyog sau cia tias muaj qhov sib txawv ntawm cov txiv apples sib txawv; Piv txwv li, cov ntsiab lus phloretin ntawm 'Liab Fuji' apples tuaj yeem ncav cuag 2.3 npaug ntawm 'Green Banana' ntau yam.
Pear (Pyrus spp.) yog qhov thib ob lub hauv paus, thiab nws cov ntsiab lus faib muaj lub cev tshwj xeeb. Ib qho kev kawm hauvPhau ntawv Journal of Agricultural thiab Food Chemistrynyob rau hauv 2023 qhia tau hais tias qhov concentration ntawmphloretinnyob rau hauv cov ntaub so ntswg nyob ib ncig ntawm pear pits yog 40% siab tshaj qhov uas nyob rau hauv lub cev nqaij daim tawv. Txawm li cas los xij, tag nrho cov ntsiab lus yog kwv yees li ib - feem peb ntawm cov txiv apples. Ntxiv rau,phloridzintau pom nyob rau hauv strawberries (Fragaria × ananassa), tab sis nws cov ntsiab lus tsuas yog 15% -20% ntawm cov uas nyob rau hauv txiv apples, thiab nws tsuas yog muaj nyob rau hauv cov txiv hmab txiv ntoo qia thiab receptacle.[3]
Nws yog tsim nyog sau cia tiasphloretinHauv cov nroj tsuag no feem ntau muaj nyob rau hauv daim ntawv ntawm glycosides. Raws li kev tshawb fawb xyoo 2022 hauvPhau ntawv Journal of Plant Physiology, dawb phloretin tsim tsawg dua 8% ntawm tag nrho cov ntsiab lus nyob rau hauv cov txiv apples tshiab, qhia txog qhov xav tau rau cov phiaj xwm hydrolysis thaum lub sij hawm rho tawm.
2, Kev sib piv ntawm Cov Txheej Txheem Kev Ua Haujlwm thiab Kev Ua Tau Zoo ntawm Cov Txheej Txheem Extraction
Tam sim no, cov kuab tshuaj extraction thiab supercritical CO₂ extraction yog thawj txoj hauv kev siv rau kev lag luam - teev ntau lawm. Hauv kev tshem tawm cov kuab tshuaj, ethanol- dej system (60-80% ethanol concentration) tau raug pov thawj tias yog cov kuab tshuaj zoo tshaj plaws, nrog cov txiaj ntsig txog li 2.8mg / g qhuav qhov hnyav tom qab 3 teev ntawm kev rho tawm ntawm 60℃thiab cov kua dej sib piv ntawm 1:15 (Food Science, 2023, Is Nrias teb 8). Txawm li cas los xij, txoj kev no ua rau muaj kev pheej hmoo ntawm cov kuab tshuaj residue, thiab cov kauj ruam tom ntej purification yog complex.
Txawm hais tias cov cuab yeej siv peev nyiaj rau supercritical CO₂ rho tawm yog qhov siab, nws muaj qhov zoo. Kev tshawb fawb tau pom tias nyob rau hauv cov xwm txheej ntawm lub siab ntawm 35MPa, qhov kub ntawm 55 degree, thiab qhov sib ntxiv ntawm 5% ethanol ua tus entrainer, tus nqi rho tawm ntawmphloretinlos ntawm cov kua pomace tuaj yeem ncav cuag ntau dua 90%, thiab purity ntawm cov khoom yog 26% siab dua li ntawm cov txheej txheem hnyav.[4]Cov thev naus laus zis no tshwj xeeb tshaj yog tsim los tsim cov khoom siv tshuaj pleev ib ce uas nkag siab rau cov kuab tshuaj residues, txawm hais tias qhov txwv solubility ntawm CO₂ mus rau cov polar tebchaw yuav tsum raug coj mus rau hauv tus account.[5]
3, Cov xwm txheej tam sim no thiab cov teeb meem ntawm kev tsim kho kev lag luam
Txawm hais tias qhov kev thov dav dav dav dav ntawmphloretin, industrialization tseem ntsib peb qhov teeb meem loj: nyob rau hauv cov nqe lus ntawm qhov chaw ruaj khov, cov kua ntau lawm cuam tshuam los ntawm huab cua. Xyoo 2022, Tuam Tshoj cov kua txiv hmab txiv ntoo yuav txo qis los ntawm 11.3% (raws li National Bureau of Statistics), ua rau muaj kev nce nqi ntawm cov khoom siv raw; Cov txheej txheem rho tawm yog ploj lawm, thiab tam sim no tsis muaj lub teb chaws tus qauv zoo rau phloretin extract; Kev hloov pauv thev naus laus zis tsis txaus, qhov kev hloov pauv hauv cheeb tsam ntawm cov khoom siv supercritical extraction tsuas yog 35%, thiab cov khoom tseem ceeb tseem cia siab rau kev xa tawm (Tuam Tshoj Pharmaceutical Equipment Report xyoo 2023).
Nyob rau hauv cov nqe lus ntawm kev ua lag luam, raws li cov ntaub ntawv los ntawm Health Industry Association, lub ntiaj teb no kev ua lag luam loj ntawmphloretincia siab tias yuav ncav cuag $ 120 lab hauv 2023, nrog cov tshuaj pleev ib ce accounting rau 62% thiab kev lag luam tshuaj suav txog 28%. Tuam Tshoj yog cov khoom lag luam thoob ntiaj teb ntawm cov kua txiv - tau los ntawm phloretin raw cov ntaub ntawv, suav txog ntau dua 50% ntawm lub ntiaj teb cov khoom. Tab sis kev ua lag luam rau siab -purity refined cov khoom tseem nyob rau hauv German thiab Japanese tuam txhab uas muag.
4, Txoj kev txhim kho yav tom ntej
Diversified txoj kev loj hlob ntawm qhov chaw: Cov kev tshawb fawb tsis ntev los no tau qhia tias cov txiv hmab txiv ntoo qus xws liMalus baccatatuaj yeem muaj txog li 2.4 npaug ntau duaphloretintshaj cultivated ntau yam (Phau ntawv Journal of Plant Resources and Environment, 2023), qhia txog lub peev xwm tseem ceeb rau kev txhim kho ntxiv.
Kev hloov kho ntsuab ntawm cov txheej txheem: Cov thev naus laus zis tshiab, suav nrog microwave- pab tshem tawm thiab sib sib zog nqus eutectic solvent extraction, tam sim no nyob rau hauv kev tshawb nrhiav, nrog cov txiaj ntsig ua ntej qhia txog 40% txo qis hauv kev siv zog. (Kev Tshawb Fawb Kev Lag Luam, 2024, Issue 1).
Kev tsim kho tus qauv: Tuam Tshoj National Institute for Food and Drug Control tau tshaj tawm txoj haujlwm tshawb fawb txog kev tswj xyuas zoo rau cov nroj tsuag rho tawm hauv 2023, thiab xav tias yuav tshaj tawm cov lus qhia cuam tshuam rau xyoo 2025.
APPCHEM tshwj xeeb hauv kev tsim cov siab -Ploretin purity rau kev siv tshuaj pleev ib ce thiab tshuaj. Peb cov khoom tau paub txog lawv qhov tshwj xeeb zoo, ruaj khov, thiab ua haujlwm tau zoo. Txhim kho koj cov tawv nqaij thiab kev noj qab haus huv formulations nrog Appchem'sphloretin,txhawb nqa los ntawm kev nruj R & D thiab kev tswj xyuas nruj. Tshawb nrhiav ntau ntxiv ntawm AppChem! (Serrisha:cwj@appchem.cn; +86-138-0919-0407)
Kev siv
[1] K. Lee, YJ Kim et al. "Cov phenolics loj hauv cov kua thiab lawv txoj kev koom tes rau tag nrho cov antioxidant muaj peev xwm". Phau ntawv Journal of Agriculture thiab Food Chemistry. [2003-09-30]
[2] 1st Kev Tshawb Fawb Lub Rooj Sib Tham ntawm Biochemistry. State University of Maringá. [2021-12]
[3] P. Hilt, A. Schieber et al. "Kev kuaj pom phloridzin hauv strawberries (Fragaria x ananassa Duch.) los ntawm HPLC-PDA-MS/MS thiab NMR spectroscopy". Phau ntawv Journal of Agriculture thiab Food Chemistry. [2003-04-04]
[4] Txhim kho thiab txhim kho enzyme- tau tsav cov thev naus laus zis los tsim cov prebiotics tshiab. Noelia Losada-García et al. [2025-04]
[5] Txoj kev rho tawm ntawm citrus tev phenolic tebchaw: kev tshuaj xyuas. N. M'hiri et al. [2014-05-19]