Dab tsi yog cov yam ntxwv ntawm phloretin?

Raws li ib tug natural dihydrochalcone compound feem ntau pom nyob rau hauv txiv hmab txiv ntoo xws li txiv apples thiab pears,phroretinyog nyiam kev tshawb fawb thiab kev loj hlob ntawm cov tshuaj pleev ib ce, khoom noj khoom haus, thiab tshuaj vim nws muaj zog antioxidant, tiv thaiv - mob, thiab ntau yam kev tu tawv nqaij.

Phloretin(CAS naj npawb: 60-82-2) yog ib qho tshwm sim ntawm polyphenolic compound, feem ntau faib rau hauv daim tawv nqaij thiab cov cag ntoo ntawm txiv apples, txiv pos nphuab, thiab qee cov nroj tsuag Rosaceae hauv qhov xwm txheej. Nws yog ib nqi sau cia hais tias nyob rau hauv cov nroj tsuag, nws feem ntau tshwm sim nyob rau hauv nws glycoside daim ntawv - Phlorizin (CAS: 60-81-1), uas muaj peev xwm yuav hydrolyzed nyob rau hauv tej yam kev mob kom tau cov cag ntoo extract.

Cov ntaub ntawv tseem ceeb chemical yog raws li nram no:
Cov mis mos molecular: C15H14O5
Molecular Luj: 274.27 g / mol

Cov qauv tshuaj tshwj xeeb no, tshwj xeeb tshaj yog ntau pawg phenolic hydroxyl hauv nws cov molecules, yog lub hauv paus tsim rau nws cov kev ua haujlwm lom neeg muaj zog, muab cov chaw tsim nyog tshuaj rau nws tus cwj pwm antioxidant.

Nkag siab txog physicochemical thaj chaw ntawm cov khoom siv raw yog thawj kauj ruam hauv kev ntsuas nws lub peev xwm rau kev thov hauv cov khoom sib txawv. Raws li tus qauv khoom cov ntaub ntawv muab los ntawm ntau tus neeg muag khoom, cov khoom siv physicochemical ntawmPhloretinmas manifested li:

• Cov tsos mob: Cov khoom ntshiab feem ntau yog dawb rau lub teeb liab lossis daj crystalline hmoov me ntsis.
• Melting point: Nws muaj qhov siab melting point ntawm 260-262℃nrog decomposition, qhia zoo thermal stability.
• Solubility: Ib tug yam ntxwv tseem ceeb ntawm phenoetin yog nws cov solubility tsawg heev nyob rau hauv dej, tab sis nws yog yooj yim soluble nyob rau hauv organic solvents xws li methanol, ethanol, acetone, ethyl acetate, thiab alkaline daws. Cov yam ntxwv no yog qhov tseem ceeb rau cov kws tsim qauv tsim, vim nws yuav tsum tau siv cov tshuaj solubilizers, nanocarriers, thiab lwm yam kev siv los txhim kho bioavailability thiab formulation stability hauv dej-raws li formulations.

Tus nqi tseem ceeb ntawm resveratrol yog nyob rau hauv nws cov kev ua ub no ntau thiab muaj zog lom neeg, ntawm cov tshuaj antioxidant thiab tiv thaiv - muaj peev xwm tiv thaiv kab mob yog tam sim no ob qhov kev tshawb fawb tob tshaj plaws thiab siv dav.

3.1 Zoo heev antioxidant muaj peev xwm thiab nws cov txheej txheem

Oxidative stress yog ib qho tseem ceeb ua rau cov tawv nqaij laus, kev puas tsuaj ntawm tes, thiab ntau yam kab mob. Raws li ib tug heev npaum antioxidant, lub mechanism ntawm kev txiav txim ntawmPhloretinyog multidimensional:
Kev tshem tawm ncaj qha ntawm cov dawb radicals: Cov phenolic hydroxyl pawg ntawm cov hauv paus bark extract molecule tuaj yeem muab hydrogen atoms, ncaj qha neutralizing ntau hom reactive oxygen (ROS) thiab hom reactive nitrogen (RNS) dawb radicals, yog li thaiv cov saw hlau ntawm oxidative puas.
Ua kom cov kab mob antioxidant endogenous: Qhov tseem ceeb tshaj, cov kev tshawb fawb tau pom tiasPhloretintuaj yeem qhib cov kab mob antioxidant tseem ceeb hauv cov hlwb. Piv txwv li, kev tshawb fawb 2019 qhia meej tiasPhloretintuaj yeem txhim kho qhov kev qhia ntawm cov khoom siv hluav taws xob nuclear E2- cuam tshuam txog 2 (Nrf2) los ntawm kev ua kom AMPK- nyob ntawm txoj kev taw qhia. Nrf2 yog lub npe hu ua "tus thawj coj-tus thawj tswj hwm" ntawm lub cellular antioxidant tiv thaiv kab mob, thiab nws qhov kev ua kom muaj peev xwm txhawb nqa cov noob qhia ntawm cov tshuaj tiv thaiv kab mob qis qis (xws li heme oxygenase-1), yog li hauv paus txhim kho lub peev xwm endogenous ntawm cov hlwb los tiv thaiv oxidative kev nyuaj siab.

3.2 Qhov tseem ceeb tiv thaiv - cov teebmeem inflammatory thiab kev tswj txoj hauv kev

Inflammation yog ze ze rau ntau yam teeb meem ntawm daim tawv nqaij (xws li pob txuv, rhiab heev, thiab pigmentation) thiab kab mob hauv lub cev.Phloretinnthuav tawm muaj zog tiv thaiv- muaj peev xwm ua rau mob, thiab nws cov txheej txheem tseem cuam tshuam nrog kev tswj hwm ntawm ntau txoj hauv kev taw qhia.

Inhibition ntawm pro-inflammatory cytokine tso tawm: Ntau qhov kev tshawb fawb hauv vitro tau lees paub tias resveratrol tuaj yeem cuam tshuam ntau yam pro-inflammatory cytokines los ntawm inflammatory cells (xws li macrophages) induced los ntawm stimuli xws li lipopolysaccharides (LPS). Hauv kev tshawb fawb luam tawm los ntawm Li Tan et al. nyob rau hauv Suav Journal of Immunology nyob rau hauv 2021, lub in vitro tiv thaiv - inflammatory mechanism ntawmPhloretinntawm LPS induced RAW264.7 macrophages tau piav qhia, thiab nws tau pom tias nws tuaj yeem cuam tshuam kev tsim cov tshuaj tiv thaiv tseem ceeb xws li nitric oxide (NO), qog necrosis factor - (TNF- ), thiab interleukin-6 (IL-6)._[2]

Tam sim no, kev lag luam ntau lawm ntawmPhloretinfeem ntau cia siab rau kev rho tawm los ntawm cov ntaub ntawv cog qoob loo uas nplua nuj nyob hauvPhloretin(xws li cov txiv apples thiab nplooj, kua pomace), thiab tom qab ntawd hydrolyzing lawv kom tau txais nws. Cov txheej txheem tsoos feem ntau yog cov kuab tshuaj extraction, tab sis cov txheej txheem tshiab extraction yog niaj hnub tshawb nrhiav los txhim kho efficiency thiab ib puag ncig tus phooj ywg.

Tsis tas li ntawd, biotransformation yog lwm qhov tseem ceeb ntawm kev siv thev naus laus zis. Ib txoj kev tshawb fawb 2018 optimized cov txheej txheem kev npaj ua tau zoo hloov cov hauv paus bark glycosides rau hauvPhloretinlos ntawm txoj kev enzymatic. Saib rau yav tom ntej, hluavtaws biology thev naus laus zis kuj qhia tau tias muaj peev xwm zoo. Los ntawm kev tsim ib txoj hauv kev biosynthetic rau hauv paus bark extract nyob rau hauv cov kab mob xws li engineered poov xab, nws yuav tsum tau tawg los ntawm kev vam khom rau cov khoom siv cog thiab ua kom tau zoo dua, ruaj khov, thiab loj - teev ntau lawm._[3]

APPCHEM

Pioneering science-rov qab cog qoob loo txij li xyoo 2006, APPCHEM(NASDAQ- npe: BON) yog FDA- soj ntsuam cov neeg tsim khoom nrog 20+ xyoo kev txawj ntse hauv cov khoom xyaw cog qoob loo. Tshwj xeeb hauv R & D, ntau lawm, thiab muab cov kev daws teeb meem rau cov khoom noj khoom haus thiab kev saib xyuas tus kheej, peb ua haujlwm thoob ntiaj teb kev lag luam nutraceutical thiab tshuaj pleev ib ce.

Tshawb nrhiav ntau ntxiv ntawm AppChem!

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Kev siv
[1]Výročná správa o činnosti a hospodárení za rok 2023. Ústav geotechniky SAV, vvi. [2024-02]
[2] Kev npaj thiab ua tus cwj pwm ntawm microcapsules los ntawm tshav kub- kho myofibrillar protein coagulation method, Zhao Lizhu, thiab al. [2023-06]
[3] Optimizing Trilobatin ntau lawm los ntawm kev tshuaj ntsuam thiab hloov kho ntawm Glycosyltransferases. Yang. ua al. [2024-01-30]