Phloretin, lub ntuj dihydrochalcone compound feem ntau muab los ntawm cov txiv hmab txiv ntoo xws li txiv apples thiab pears, tau txais kev lees paub hauv kev lag luam tu tawv nqaij vim nws muaj peev xwm antioxidant. Raws li ib qho ntawm cov khoom xyaw tseem ceeb ntawm lub qhov dej -paub hom tshuaj tiv thaiv antioxidant, nws tau ntseeg tias muaj peev xwm tiv taus lub teeb puas thiab ib puag ncig siab. Txawm li cas los xij, cov lus nug nyuaj dua tshwm sim: Phloretin puas muaj txiaj ntsig zoo rau rosacea?
Rosacea - Kev sib tw tawv nqaij tawv
Rosacea yog ib hom kab mob inflammatory ntawm daim tawv nqaij uas muaj ntau yam kev kho mob tshwm sim, uas tshwm sim los ntawm erythema tsis tu ncua, telangiectasia, papules, thiab pustules nyob rau hauv nruab nrab ntawm lub ntsej muag.[1] Yog li ntawd, ib qho kev cuam tshuam zoo tshaj plaws rau rosacea yuav tsum muaj tsawg kawg ib lossis ntau lub peev xwm ntawm kev tiv thaiv - mob, tiv thaiv kab mob - tswj, antioxidant, lossis txhim kho vascular muaj nuj nqi.
Kev Ua Txhaum Cai Li Cas ntawm Phloretin?
Phloretin, raws li ib qho tseem ceeb ntawm flavonoid compound, tau lees paub tias muaj kev ua haujlwm lom neeg hauv ntau cov kev tshawb fawb hauv paus. Cov kev tshawb fawb no muab lub hauv paus theoretical rau kev ntsuam xyuas nws cov peev txheej hauv rosacea.
1. Muaj peev xwm antioxidant zoo:
Qhov zoo tshaj plaws - paub tus yam ntxwv ntawmPhloretinyog nws cov haujlwm muaj zog antioxidant. Nws tuaj yeem cuam tshuam cov dawb radicals uas tsim los ntawm cov yam ntxwv xws li hluav taws xob ultraviolet thiab ib puag ncig muaj kuab paug, yog li txo cov oxidative kev nyuaj siab rau cov tawv nqaij. [5] Nyob rau hauv lub npe nrov SkinCeuticals 'Phoretin CF essence, 2% ntawm Philoretin, 10% ntawm vitamin C, thiab 0.5% ntawm ferulic acid ua hauj lwm ua ke los tsim ib tug patented broad -spectrum antioxidant system, uas muaj peev xwm ho txhim kho daim tawv nqaij lub peev xwm los tiv thaiv lub teeb puas. Xav tias oxidative kev nyuaj siab kuj tuaj yeem ua rau cov lus teb inflammatory ntawm rosacea,Phloretin's antioxidant zog yog theoretically zoo rau alleviating cov tsos mob ntawm rosacea.
2. Ntshiab anti-inflammatory mechanism:
Qhov no yog qhov sib koom ua ke muaj zog tshaj plaws ntawmPhloretinthiab rosacea. Ntau qhov kev tshawb fawb hauv vitro tau qhia tias Phloretin muaj cov tshuaj tiv thaiv tseem ceeb - muaj peev xwm ua rau mob. Kev tshuaj xyuas lub npe 'Lub Molecular Pharmacology ntawm Phloretin: Anti-Inflammatory Mechanisms of Action', luam tawm nyob rau hauv phau ntawv journal Biomedicines hauv 2023, tau sau tseg nws cov tshuaj tiv thaiv - mob. Cov kev tshawb fawb tshwj xeeb tshaj tawm qhia tias Phloretin tuaj yeem siv nws cov teebmeem los ntawm inhibiting inflammatory signaling pathways. Piv txwv li, cov kev tshawb fawb tau pom tias Phloretin tuaj yeem cuam tshuam tus xov tooj -zoo li receptor 2 (TLR2) thiab nws cov dej ntws qis MyD88/NF-κB taw qhia txoj hauv kev.[6] Raws li tau hais ua ntej, kev ua kom ntau dhau ntawm TLR2 txoj hauv kev yog ib qho ntawm cov tseem ceeb tsav tsheb rau cov lus teb inflammatory hauv rosacea.[7] Los ntawm inhibiting txoj kev no, phloretin tuaj yeem theoretically cuam tshuam ncaj qha rau hauv cov txheej txheem inflammatory txheej txheem ntawm rosacea, txo qhov tsim ntawm inflammatory yam xws li COX-2, thiab yog li alleviate erythema thiab papules.
Dab tsi yog Daim Ntawv Thov Kev Pom Zoo thiab Cov Teeb Meem ntawm Phloretin?
Txawm hais tias kev tshawb fawb yav tom ntej tau lees paub qhov ua tau zoo ntawmphloretin, nws daim ntawv thov ua tiav hauv rosacea cov khoom tu tawv nqaij tseem ntsib ntau yam teeb meem.
Formula stability thiab irritability:
Phloretin Nws ua rau muaj kev ruaj ntseg tsis zoo nyob rau hauv cov kev daws teeb meem aqueous, tshwj xeeb tshaj yog nyob rau hauv nruab nrab lossis me ntsis alkaline ib puag ncig, thiab nws muaj oxidation thiab degradation. Kev tshawb fawb tau pom tias nws ruaj khov nyob rau hauv acidic ib puag ncig nrog pH tus nqi qis dua 3.5. Qhov no piav qhia vim li cas cov khoom lag luam muajphloretin, xws li Phloretin CF, feem ntau muaj pH tus nqi ntawm 2.0-3.5.[4] Txawm li cas los xij, tus nqi pH qis no yuav ua rau muaj kev kub ntxhov loj rau cov neeg mob rosacea, uas nws cov tawv nqaij barrier twb puas lawm thiab rhiab heev, yooj yim ua rau intolerance tshua xws li stinging thiab liab. Yuav ua li cas los tsim cov mis mos thiab qis qis thaum ua kom nws cov dej num yog ib qho kev sib tw loj rau cov formulators.
Yog xav paub ntxiv txogPhloretinthiabPhlorizin, txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn; +86-138-0919-0407)
Kev siv
[1] Kev tshawb fawb tau nce qib ntawm kev kho mob rosacea- ntsig txog erythema thiab yaug nrog botulinum toxin. Zhang Jie [2025-08]
[2] Kev kho muaj peev xwm ntawm flavonoids hauv kev tswj hwm psoriasis. Narendra Pentu et al. [2024-01-03]
[3] Macrophages hauv rosacea: pathogenesis thiab kho muaj peev xwm. Xiaolin Wang et al. [2025-07-31]
[4] PHLORETIN CF yog ib qho muaj zog ANTIOXIDANT FACE SERUM uas muaj kev sib xyaw ua ke ntawm 2% PHLORETIN, 10% PURE VITAMIN C (L-ASCORBIC ACID), thiab 0.5% FERULIC ACID [2020-3]
[5]B. Rezk, G. Haenen et al. "Kev ua haujlwm antioxidant ntawm phloretin: nthuav tawm cov tshuaj antioxidant tshiab hauv flavonoids." Kev sib txuas lus biochemical thiab biophysical tshawb fawb (2002). [2002-07-05]
[6]Phloretin txo qis qhov mob tshwm sim los ntawm subarachnoid hemorrhage los ntawm kev tswj hwm ntawm TLR2/MyD88/NF-kB txoj kev. Xudong Hao et al.