Puas yog NMN tsuas yog vitamin B3?

Nyob rau niaj hnub no cov nroj tsuag extract thiab kev noj qab haus huv kev lag luam,NMN ( -nicotinamide mononucleotide)yog undoubtedly lub qhov muag tshaj plaws -catch "lub hnub qub molecule" nyob rau hauv xyoo tas los no. Nws sai sai ua lag luam thoob ntiaj teb nrog nws lub peev xwm los tiv thaiv - laus, ua rau muaj kev txaus siab ntawm peev thiab nrhiav cov neeg siv khoom. Txawm li cas los xij, nyob rau hauv hype, ib qho tseem ceeb tseem ceeb cov lus nug tseem ceeb tau nyob rau hauv ob qho tib si sab hauv thiab sab nraum kev lag luam: dab tsi raws nraim yog dab tsi?NMN? Dab tsi yog kev sib raug zoo ntawm nws thiab qhov zoo - paub vitamin B3? Qee tus neeg hais tias nws yog cov txiaj ntsig ntawm vitamin B3, thaum lwm tus tsuas yog sib npaug nrog "vitamin B3 kim dua".

Kom paub meej txog kev sib raug zoo ntawmNMNthiab vitamin B3, peb yuav tsum pib nrog lub hauv paus ntawm biochemistry: metabolic pathways.

Ua ntej, vitamin B3 tsis yog ib qho kev sib xyaw ua ke, tab sis cov ntsiab lus dav dav rau cov chav kawm ntawm cov khoom uas muaj cov qauv zoo sib xws thiab kev ua ub no ntawm lub cev. Nws cov ntaub ntawv tseem ceeb thiab feem ntau yog niacin thiab nicotinamide (NAM). Raws li ib qho ntawm cov vitamins B tseem ceeb rau tib neeg lub cev, nws ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev noj qab haus huv thiab txhawb kev noj qab haus huv ntawm daim tawv nqaij. Kev tsis txaus vitamin B3 hnyav tuaj yeem ua rau Pellagra, ib qho kev noj zaub mov tsis zoo.

NMN, lub npe tag nrho yog "-nicotinamide mononucleotide", thiab nws txoj kev sib raug zoo nrog nicotinamide tuaj yeem pom los ntawm nws lub npe. Hauv tib neeg lub cev, NMN yog cov khoom tseem ceeb ua ntej rau kev tsim cov coenzyme tseem ceeb, nicotinamide adenine dinucleotide (NAD +). metabolism, DNA kho, cell signaling, thiab gene qhia kev cai.

Hauv tib neeg lub cev, muaj peb txoj hauv kev tseem ceeb los tswjNAD + qib, ntawm qhov tseem ceeb tshaj plaws yog "Salvage Pathway". Hauv txoj kev no, vitamin B3 (tshwj xeeb yog nicotinamide, NAM) yog cov khoom pib. Nws hloov mus rau NMN raws li catalysis ntawm ib qho enzyme hu ua nicotinamide phosphoribosyltransferase (Nampt). Tom qab ntawd, NMN tau txuas ntxiv rau hauv NAD+.

Txoj kev no qhia meej txog kev sib raug zoo ntawm peb:
Vitamin B3 (nicotinamide) → Nampt enzyme action → NMN → multi- kauj ruam → NAD +

Nws pom tau tiasNMNNws yog ib qho derivative ntawm vitamin B3. Txawm li cas los xij, kev sib npaug ntawm ob yuav yog qhov yuam kev ntawm kev ua kom dav dav. NMN yog qhov qis dua hauv cov saw hlau metabolic dua li cov vitamin B3, thiab nws yog tus thawj coj ncaj qha ntawm NAD+. Qhov no txhais tau hais tias txoj kev xav, ntxiv NMN tuaj yeem ncaj qha thiab nrawm dua tus nqi- txwv cov kauj ruam ntawm Nampt enzyme, muaj peev xwm ua rau muaj txiaj ntsig ntau ntxiv hauv intracellular NAD + qib. Qhov no yog precisely lub ntsiab logic ntawmNMNua ib qho ntxiv. Yog li, nws tsis yog qhov tseeb hais tias NMN yog "vitamin B3". Ib nqe lus nruj dua yog tias NMN yog ib qho tseem ceeb hauv nruab nrab metabolite hauv cov txheej txheem ntawm kev hloov cov vitamin B3 rau hauv lub ntsiab coenzyme NAD + hauv tib neeg lub cev.

NMN tsis yog vitamin B3, tab sis ib qho kev txuas ntxiv thiab hloov kho ntawm nws cov txiaj ntsig saw

Raws li kev txheeb xyuas saum toj no, peb tuaj yeem kos cov lus xaus hauv qab no:

1. Qhov tseem ceeb sib txawv:NMNyog ib tug metabolic derivative ntawm vitamin B3 (nicotinamide) nyob rau hauv lub cev thiab ib tug ncaj precursor rau lub synthesis ntawm NAD +. Nws txoj hauj lwm nyob rau hauv txoj kev metabolic yog qhov tseem ceeb thiab ncaj qha tshaj vitamin B3, thiab ob qho tib si tsis tuaj yeem sib npaug.
2. Cov peev txheej sib txawv: Txawm hais tias NMN ib txwm muaj nyob hauv cov nroj tsuag, nws cov ntsiab lus tsawg kawg nkaus thiab tsis muaj txiaj ntsig kev lag luam rho tawm. Lub ntsiab ntawm NMN raw cov ntaub ntawv muaj nyob rau hauv kev ua lag luam yog los ntawm cov roj ntsha fermentation los yog enzymatic synthesis, uas yog cov khoom ntawm biotechnology es tsis yog cov tsoos "cog extracts".
3. Kev ua lag luam thiab kev tswj hwm yog txawv:NMN, raws li qhov tshwm sim los tiv thaiv- lub tswv yim kev laus, muaj kev lag luam loj thiab loj hlob sai, tab sis nws txoj cai tswj hwm thoob ntiaj teb tsis meej meej, tshwj xeeb tshaj yog hauv Suav teb av loj, qhov twg nws tseem tsis tau txais kev cai lij choj. Qhov no yog qhov tsis sib xws rau vitamin B3 raws li kev paub tab thiab ua raws li cov khoom noj.

Rau cov nroj tsuag extract kev lag luam, sawv ntawmNMNyog ib rooj plaub uas txhawb siab heev. Nws nthuav tawm qhov kev thov loj ntawm cov neeg siv khoom rau siab - thev naus laus zis, ua tau zoo, thiab cov khoom noj khoom haus meej meej.

Hauv cov ntsiab lus, 'NMN yog vitamin B3' yog ib qho yooj yim heev thiab tsis meej pem.NMNyog ib qho molecule nrhiav tau los ntawm - kev tshawb fawb tob hauv kev tshawb fawb txog lub neej niaj hnub raws li cov vitamin B3, uas ua tiav qhov kev vam meej hauv cov saw muaj nuj nqis. Kev nkag siab txog qhov no yog qhov tseem ceeb rau peb kom nkag siab txog txoj kev loj hlob ntawm cov khoom siv raw rau yav tom ntej.

Yog xav paub ntxiv txogNMN, txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn; +86-138-0919-0407)

Kev siv
[1] Y. Guan, Su Wang et al. "Nicotinamide Mononucleotide, NAD + Precursor, Rescues Age-Txoj kev cuam tshuam rau AKI hauv Sirtuin 1-Dependent Manner." Phau ntawv Journal ntawm American Society of Nephrology: JASN (2017).
[2] Bin Yu, Xiaotong Jing et al. "Ntau yam khoom siv ntau yam-NMN: nws cov yam ntxwv tshwj xeeb, cov khoom siv hauv lub cev, cov tshuaj pharmacodynamic, kev sim tshuaj, thiab ntau yam kev siv." Frontiers hauv Pharmacology (2024).
[3] Chaolan Li, Zou Long et al. "Kev tshuaj ntsuam xyuas ntawm Natural High- tsim NMN hom thiab Microbial Synthesis ntawm NMN los ntawm Nampt." Khoom noj khoom haus Chemistry (2023).
[4] Jing YJ, Takumi Sakamoto et al. "Cinnamomum verum J. Presl Bark muaj cov ntsiab lus siab ntawm Nicotinamide Mononucleotide." Molecules (2022).
[5]Ye Liu, Jin-Song Gong et al. "Technology thiab kev nkag siab ua haujlwm rau nicotinamide mononucleotide rau tib neeg noj qab haus huv." Siv Microbiology thiab Biotechnology (2023).