Phloretin siv rau dab tsi?

Phloretinyog ib txwm tshwm sim dihydrochalcone flavonoid compound pom nyob rau hauv cov txiv hmab txiv ntoo xws li txiv apples. Nyob rau hauv xyoo tas los no, nws tau txais kev saib xyuas thoob plaws hauv cov nroj tsuag extract kev lag luam thiab biomedical kev tshawb fawb teb. Kev tshawb fawb tau pom tias Phloretin nthuav tawm ntau yam kev ua ub no, suav nrog cov tshuaj tua kab mob antioxidant, tiv thaiv - mob, tiv thaiv - qog, thiab kev tswj cov metabolism hauv kev tshawb fawb hauv chav kuaj._[1]

Phloretinyog ib tug polyphenolic compound uas belongs rau pawg dihydrochalcone nyob rau hauv cov nqe lus ntawm cov qauv tshuaj. Nws yog ib txwm enriched nyob rau hauv daim tawv nqaij, hauv paus bark, thiab ceg ntawm txiv apples thiab pears, nrog txiv apples yog nws thawj coj mus muag qhov chaw ntawm extraction. Nyob rau hauv cov nqe lus ntawm lub cev muaj zog, Phloretin zoo nkaus li ib tug dawb mus rau daj ntseg daj crystalline hmoov nrog tshwj xeeb solubility yam ntxwv. Txhawm rau kom ntseeg tau tias nws cov dej num, feem ntau nws raug pom zoo kom khaws nws hauv qhov chaw qis - qhov kub thiab txias, tsaus, thiab qhov chaw qhuav. Cov yam ntxwv tseem ceeb no txiav txim siab cov txheej txheem uas yuav tsum tau ua rau nws cov kev tshawb fawb thiab kev tsim kho, kev tsim khoom, thiab kev siv.

Tus nqi ntawm Phloretin yog feem ntau xav txog hauv nws cov kev ua ub no thiab muaj zog lom neeg, thiab kev tshawb fawb tam sim no yog tsom rau theem preclinical, encompassing ntau theem ntawm hlwb mus rau tsiaj qauv.

2.1Antioxidant thiab tiv thaiv - cov teebmeem

Antioxidative thiab tiv thaiv - cov teebmeem inflammatory yog ib qho ntawm feem ntau kawm txog cov haujlwm tseem ceeb ntawm phloretin. Raws li ib qho flavonoid compound, nws cov qauv molecular ua rau nws muaj txiaj ntsig zoo tshem tawm cov dawb radicals thiab txo oxidative kev nyuaj siab rau lub cev._[2]Ntau qhov kev tshawb fawb tau lees paub tias phenoetin tuaj yeem ua rau muaj txiaj ntsig zoo los tiv thaiv - mob los ntawm inhibiting qhov tsim ntawm cov kab mob inflammatory thiab ua kom muaj kev cuam tshuam ntawm cov teeb meem._[3] Piv txwv li, kev tshawb fawb tau qhia tiasphloretintuaj yeem txhim kho cov lus teb inflammatory, muab lub hauv paus theoretical rau nws daim ntawv thov hauv kev saib xyuas tawv nqaij (xws li photoprotection, o nyem) thiab tiv thaiv kev mob ntev - kab mob ntsig txog.

2.2 Kev tswj hwm metabolic: kev tshawb fawb tau zoo

Kev tswj hwm lub luag haujlwm ntawm Phloretin hauv metabolic syndrome thiab lwm yam kab mob yog tam sim no kev tshawb fawb hotspot. Raws li xyoo 2024, thaum tsis muaj kev sim tshuaj ntsuam xyuas tseem tau luam tawm ntawm kev siv ncaj qha ntawm phloretin rau kev kho mob metabolic hauv tib neeg, kev tshawb fawb tsiaj ntau yam qhia tau tias muaj peev xwm kho tau zoo.

① Txhim kho cov piam thaj thiab lipid metabolism: Kev tshawb fawb tau pom tiasPhloretintuaj yeem txhim kho cov piam thaj tsis kam rau siab thiab insulin tsis kam ua los ntawm kev noj zaub mov muaj roj ntau._[1]Nws tswj cov ntshav qabzib hauv cov ntshav los ntawm kev cuam tshuam rau kev ua haujlwm ntawm cov piam thaj thauj khoom, thiab tseem cuam tshuam rau cov metabolism hauv lipid, pab txo cov ntshav lipids thiab tiv thaiv cov rog tsis zoo.
② Sib ntaus rog rog thiab rog daim siab: Phloretin tau qhia lub peev xwm los txo qhov hnyav nce thiab txhim kho daim siab steatosis (fatty siab) hauv siab - noj zaub mov rog - ntxias cov tsiaj rog rog._[1] Raws li kev tshawb fawb xyoo 2020, Phloretin tuaj yeem txhim kho hepatic steatosis hauv cov nas rog rog los ntawm kev tswj hwm SIRT1 / AMPK txoj kev taw qhia thiab inhibiting hepatic fat production._[4]Qhov no nthuav tawm nws cov peev txheej hauv kev txhim kho cov khoom lag luam rau kev tiv thaiv lossis kev kho mob ntxiv ntawm tsis yog -alcoholic fatty siab kab mob (NAFLD).
③ Lub peev xwm ntawm SGLT inhibitors: Phloridzin, derivative ntawm Phloretin, yog ib qho ntawm thawj zaug kawm sodium glucose cotransporter (SGLT) inhibitors. Txawm hais tias cov nyhuv inhibitory ntawm Phloretin nws tus kheej ntawm SGLT tsis zoo ib yam li ntawm nws cov derivatives, nws cov qauv muab cov qauv coj ua tseem ceeb rau kev txhim kho cov tshuaj tiv thaiv ntshav qab zib tshiab._[5]

2.3 Antitumor muaj peev xwm

Phloretin kuj tau qhia qhov kev cia siab zoo hauv kev tshawb fawb txog qog noj ntshav. Ntau qhov kev sim hauv vitro cell thiab qee qhov kev tshawb fawb tsiaj tau pom tiasPhloretintuaj yeem inhibit qhov kev loj hlob ntawm ntau cov qog hlwb, ua rau lawv cov apoptosis, thiab tuaj yeem thaiv cov txheej txheem ntawm cov qog metastasis._[3]

Nws cov txheej txheem ntawm kev ua haujlwm yog qhov nyuaj thiab tuaj yeem koom nrog kev tswj hwm ntawm ntau lub xov tooj ntawm tes taw qhia txoj hauv kev. Txawm li cas los xij, cov kev tshawb pom no tseem nyob rau theem pib ntawm kev tshawb fawb, thiab tseem muaj txoj hauv kev ntev mus ua ntej lawv loj hlob los tiv thaiv -cov tshuaj qog nqaij hlav lossis kev xaiv kho mob ntxiv.

2.4 Lwm Yam Kev Tshawb Fawb Txog Kev Tshawb Fawb

Tsis tas li ntawd, txoj kev tshawb fawb kuj pom tiasPhloretinmuaj ntau yam kev ua ub no lom neeg, xws li inhibiting kev tsim cov kab mob tshwj xeeb biofilms thiab muaj peev xwm tiv thaiv cov teebmeem neuroprotective._[2]Cov lus qhia ntau yam kev tshawb fawb no nthuav dav ntxiv rau qhov chaw xav txog yav tom ntej ntawm Phloretin.

Txawm hais tias kev txhawb nqa cov txiaj ntsig ntawm kev tshawb fawb yooj yim, Phloretin tseem ntsib cov teeb meem loj hauv kev txhais nws rau hauv cov khoom lag luam thiab kev siv tshuaj kho mob.

3.1 Qhov chaw tsis muaj nyob rau hauv daim ntawv thov kev kho mob thiab cov kws tshuaj pharmacopoeia suav nrog

Qhov no tam sim no yog qhov tseem ceeb tshaj plaws hauv kev siv Phloretin. Los ntawm kev tshawb nrhiav cov ntaub ntawv raug cai, tam sim no tsis muaj pov thawj los qhia tias Phloretin suav nrog hauv Suav Pharmacopoeia (suav nrog cov qauv tsim nyog lossis cov tshuaj ntxiv hauv 2023). Lub caij no, nws lub xub ntiag tsis tau pom nyob rau hauv cov npe tshuaj ntawm cov koom haum tso cai thoob ntiaj teb xws li World Health Organization (WHO). Qhov no txhais tau tiasPhloretintseem tsis tau raug lees paub tias yog cov khoom siv tshuaj muaj txiaj ntsig, thiab tsis muaj kev cai lij choj ntawm nws cov lus qhia, kev siv, thiab ntau npaum li cas.
Tsis tas li ntawd, raws li tau hais dhau los, muaj qhov tsis muaj qhov tseem ceeb ntawm qhov siab - zoo, cov phooj ywg- tau tshuaj xyuas tib neeg cov txiaj ntsig kev sim tshuaj ntawm nws daim ntawv thov hauv thaj chaw tseem ceeb xws li metabolic syndrome. Qhov "kev hloov pauv hloov pauv" los ntawm chav kuaj mus rau qhov chaw kho mob zoo heev txwv nws txoj kev thov kev cai lij choj thiab kev nce qib hauv kev lag luam tshuaj.

3.2 Daim ntawv thov hauv cov tshuaj pleev ib ce thiab zaub mov

Raws li nws muaj zog antioxidant thiab tiv thaiv - cov khoom ua kom mob,Phloretinmuaj ib tug kuj mature daim ntawv thov nyob rau hauv lub teb ntawm tshuaj pleev ib ce. Nws yog feem ntau ntxiv rau cov khoom tu tawv nqaij xws li essence thiab lub ntsej muag qab zib ua antioxidant los pab tiv thaiv cov tawv nqaij laus los ntawm ultraviolet rays thiab ib puag ncig muaj kuab paug, thiab muaj qee yam ua kom dawb thiab soothing._[6]Txawm li cas los xij, cov ntawv thov no feem ntau tsis yog - ntawv tshuaj thiab tsis yog - kho mob, thiab lawv cov lus thov ntau npaum li cas thiab cov txiaj ntsig tau raug tswj hwm nruj me ntsis thoob plaws ntau lub tebchaws.

Hauv cov ntsiab lus,Phloretinyog ib tug natural active ingredient uas muaj peev xwm loj hlob. Nws cov dej num lom zem ntau hauv cov tshuaj tua kab mob antioxidant, tiv thaiv - mob, thiab tshwj xeeb tshaj yog cov kev cai metabolic tau raug lees paub nyob rau hauv ntau cov kev tshawb fawb preclinical, uas qhia tau hais tias nws cov kev siv dav dav hauv cov khoom noj khoom haus, tshuaj pleev ib ce, thiab txawm tias yav tom ntej kev txhim kho tshuaj.

Yog xav paub ntxiv, thov txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn;+86-138-0919-0407)

Siv:

[1]Sary Alsanea, Mingming Gao et al. "Phloretin tiv thaiv siab-Kev noj zaub mov rog-Ua kom rog rog thiab txhim kho Metabolic Homeostasis." The AAPS Journal. [2017-02-14]

[2]Jin-Hyung Lee, S. Regmi et al. "Apple Flavonoid Phloretin Inhibits Escherichia coli O157: H7 Biofilm Tsim thiab Ameliorates Colon Inflammation nyob rau hauv nas." Kab mob thiab tiv thaiv kab mob. [2011-09-19]
[3] Lijie Ma, Ruixuan Wang et al. "Phloretin nthuav tawm cov tshuaj tiv thaiv kab mob qog noj ntshav thiab txhim kho lub peev xwm tiv thaiv qog noj ntshav ntawm cisplatin ntawm cov tsis yog - cov kab mob qog nqaij hlav qog nqaij hlav me me los ntawm kev tswj hwm kev qhia ntawm apoptotic txoj hauv kev thiab matrix metalloproteinases." International Journal of oncology. [2016-02-01]
[4] Phloretin ameliorates hepatic steatosis los ntawm kev tswj ntawm lipogenesis thiab Sirt1 / AMPK signaling hauv cov nas rog rog. [2020-09-29]
[5] Kev kho mob qhia txog Phloridzin: Ib qho Gleam tshiab rau cov kab mob metabolic. Harshal Dipak Borse et al. [2025-05]
[6] C. Wu, Y. Ho, et al. "Nyob rau hauv vitro thiab hauv vivo txoj kev tshawb fawb ntawm phloretin-induced apoptosis hauv tib neeg lub siab mob qog noj ntshav nrog inhibition ntawm hom II glucose transporter." International Journal of Cancer. [2009-05-01]