Dab tsi yog Phloretin Muaj?

Nyob rau niaj hnub no cov tshuaj pleev ib ce thiab cov khoom noj khoom haus ua lag luam,Phloretinyog undoubtedly ib lub hnub qub nce. Nws yog lub npe hu ua "whitening gold" vim nws zoo heev antioxidant, tiv thaiv -inflammatory, thiab whitening muaj peev xwm, thiab yog heev nyiam los ntawm formulators thiab cov neeg siv khoom. Dab tsi yog Phloretin tsim los ntawm? "Qhov no tsis yog tsuas yog ib qho teeb meem tshuaj lom neeg yooj yim xwb, tab sis kuj muaj feem xyuam nrog kev ntseeg siab ntawm nws qhov chaw, kev vam meej ntawm nws cov txheej txheem tsim khoom, thiab kev lag luam yav tom ntej.

Los ntawm kev xav ntawm cov qauv tshuaj,Phloretintsis yog ib tug complex molecule, tab sis nws cov qauv tshwj xeeb endows nws muaj zog lom kev ua si. Phloretin belongs rau ib qho subclass ntawm ntuj flavonoids - dihydrochalcones. Nws cov core molecular skeleton yog classical C6-C3-C6 qauv._[1]
Nws yog ib nqi sau cia hais tias nyob rau hauv cov xwm, Phloretin feem ntau muaj nyob rau hauv nws glycosidic daim ntawv, Phlorizin. Phlorizin yog ib qho kev sib txuas tsim los ntawm kev sib txuas cov piam thaj molecule rau pawg hydroxyl ntawm 2'- txoj hauj lwm ntawm Phloritin. Hauv cov nroj tsuag, daim ntawv khaws cia ntawm Phloretin yog qhov ruaj khov thiab muaj ntau. Txawm li cas los xij, thaum lub sij hawm rho tawm lossis thov, Phloretin nrog cov khoom siv roj ntsha ntau dua tuaj yeem tau txais los ntawm hydrolysis thiab tshem tawm cov piam thaj hauv pawg.

Tus nqi lag luam ntawm Phloretin pib nrog nws qhov chaw. Nws tsuas yog muaj nyob rau hauv cov txiv hmab txiv ntoo muaj kua, tshwj xeeb tshaj yog nyob rau hauv cov txiv hmab txiv ntoo, tawv nqaij, hauv paus bark, thiab nplooj ntawm txiv apples (Malus domestica) thiab pears (Pyrus communis)._[1]Ntawm lawv, txiv apples yog qhov tseem ceeb tshaj plaws kev lag luam nrhiav pom ntujPhloretin(thiab Phlorizin) rau hnub tim. Qhov no tsis tsuas yog piav qhia vim li cas cov kua txiv hmab txiv ntoo thiaj li nrov hauv cov khoom tu tawv nqaij, tab sis kuj muab cov khoom siv raw rau kev tsim cov Phloretin thaum ntxov.
Lub hauv paus yog vim li cas cov nroj tsuag sib xyaw cov tebchaw no yog kev tiv thaiv kev tiv thaiv tiv thaiv ultraviolet hluav taws xob, kab mob ntxeem tau, thiab kev puas tsuaj oxidative. Nws tuaj yeem hais tau tias Phloretin yog "natural sunscreen" thiab "antibacterial agent" uas cov nroj tsuag tau hloov zuj zus mus rau lub sijhawm ntev ntawm evolution kom hloov mus rau lawv ib puag ncig.

Nyob rau theem cellular, txoj kev biosynthesis ntawmPhloretinbelongs rau ib ceg ntawm flavonoid synthesis txoj kev._[2]Cov txheej txheem synthesis tuaj yeem raug sau tseg raws li cov kauj ruam tseem ceeb hauv qab no:
1. Tsim cov substrates pib: Txoj hauv kev no pib nrog phenylalanine thiab tsim 4-coumaroyl-CoA los ntawm cov tshuaj tiv thaiv, uas yog ib qho ua ntej rau kev sib txuas ntawm ntau cov phenolic tebchaw.

2. Cov kauj ruam txo qis: Tsis zoo li cov synthesis ntawm lwm cov flavonoids xws li naringenin, txoj kev sib txuas ntawm Phloretin muaj cov kauj ruam tshwj xeeb. Raws li catalysis ntawm NADPH-dependent ob daim ntawv cog lus reductase (DBR), ob daim ntawv cog lus ntawm C3 saw ntawm 4-coumaroyl-CoA raug txo kom ua 4-dihydrocoumaroyl-CoA. Cov kauj ruam no yog qhov tseem ceeb hauv kev txiav txim siab cov kev taw qhia ntawm cov khoom mus rau cov qauv dihydrochalcone.

3. Skeleton kev tsim kho: Tom qab, nyob rau hauv catalysis ntawm Chalcone Synthase (CHS), ib tug molecule ntawm 4-dihydrocoumaroyl CoA undergoes ib tug condensation cov tshuaj tiv thaiv nrog peb molecules ntawm malonyl CoA, thaum kawg cyclizing los tsim C6-C3-C6 lub hauv paus skeleton ntawm Phloretin.

4. Kev hloov kho Glycosylation: Hauv cov nroj tsuag, Phloretin synthesized yog ntxiv hloov los ntawm glycosyltransferases, uas ua ke nrog cov piam thaj los ua Phloretin rau kev khaws cia thiab kev thauj mus los.

Tom qab nkag siab txog cov peev txheej ntuj thiab txoj hauv kev biosynthetic ntawmPhloretin, peb ib txwm them sai sai rau nws cov txheej txheem ntau lawm. Tam sim no, muaj ob txoj hauv kev tseem ceeb rau kev tsim Phloretin:

1. Tsob nroj rho tawm:

Qhov no yog txoj kev classic tshaj plaws, uas suav nrog kev rho tawm thiab ntxuav cov ntaub ntawv cog qoob loo uas nplua nuj nyob hauv Phloretin (tsuas yog los ntawm -cov khoom xws li kua txiv hmab txiv ntoo thiab kua pomace) siv cov kuab tshuaj. Txawm hais tias technically paub tab thiab ib txwm muab los, txoj kev no ntsib cov teeb meem, suav nrog cov khoom lag luam qis, cov nqi purification siab, thiab rhiab heev rau lub caij nyoog thiab cov khoom siv raw variations.

2. Biological synthesis (synthetic biology):

Nrog rau txoj kev loj hlob sai ntawm cov cuab yeej siv hluav taws xob hluavtaws, siv cov kab mob ua "cell factories" los tsim Phloretin tau dhau los ua qhov kev tshawb fawb hotspot thiab cov kev taw qhia yav tom ntej. Cov kws tshawb fawb tau siv cov txheej txheem kev tsim cov noob caj noob ces los hloov pauv tag nrho cov tshuaj tiv thaiv enzymatic txoj hauv lub luag haujlwm rau kev tsim cov cag ntoo extract los ntawm cov nroj tsuag (xws li cov enzymes tseem ceeb DBR, CHS, thiab lwm yam) rau hauv cov poov xab los yog Escherichia coli.

Rov qab mus rau peb lo lus nug thawj zaug: 'Phloretin yog dab tsi?'? "Cov lus teb yog ntau-level:

• Chemically, nws yog dihydrochalcone compound uas muaj ob lub nplhaib benzene thiab peb -carbon saw.
• Nyob rau hauv cov xwm, nws yog ib tug natural khoom synthesized los ntawm cov nroj tsuag xws li txiv apples los ntawm photosynthesis thiab complex theem nrab metabolic txoj kev.
• Technically, nws tuaj yeem muab rho tawm los ntawm cov nroj tsuag los yog ua tau zoo thiab ruaj khov los ntawm kev siv biotechnology niaj hnub siv microbial fermentation.

APPCHEM tshwj xeeb hauv kev tsim cov siab -Ploretin purity rau kev siv tshuaj pleev ib ce thiab tshuaj. Peb cov khoom tau paub txog lawv qhov tshwj xeeb zoo, ruaj khov, thiab ua haujlwm tau zoo. Txhim kho koj cov tawv nqaij thiab kev noj qab haus huv formulations nrog Appchem'sphloretin,txhawb nqa los ntawm kev nruj R & D thiab kev tswj xyuas nruj. Tshawb nrhiav ntau ntxiv ntawm AppChem! (Serrisha:cwj@appchem.cn; +86-138-0919-0407)

Kev siv
[1]L. Wang, Li J, et al. "Synthesis, Crystal Structure, thiab Kev Ntsuam Xyuas Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb ntawm Phloretin Derivatives." Molecules. [2014-10-01]
[2]Wei Lingzhen, et al.Kev tshawb fawb txog biosynthesis ntawm flavonoids thiab lawv daim ntawv thov hauv tshuaj pleev ib ce.
[3] 8. Phloretin: Ib Lub Ntuj Dihydrochalcone nrog Promising Anti-Cancer Potential. Abkin SV. [2024-03-30]