Cov txiv apples puas pab txo cov roj cholesterol?

Raws li cov txiv hmab txiv ntoo thoob ntiaj teb nrog kev tsim khoom txhua xyoo ze li 50 lab tons,txiv apples(Malus domestica) tau dhau los ua lub ntsiab lus kub ntawm kev txhawj xeeb hauv kev lag luam thiab kev kawm vim muaj peev xwm ntawmpolyphenolsmuab rho tawm los ntawm lawv cov txheej txheem los ntawm - cov khoom hauv kev tswj cov ntshav lipids. Txawm li cas los xij, ib qho teeb meem tseem ceeb yeej ib txwm plagued rau sab sauv thiab nqes dej ntawm kev lag luam saw:

Ua li Kua Extractmuaj pov thawj txaus rau tib neeg cov ntaub ntawv kho mob los txhawb nws qhov kev thov ntawm "kev pab txo cov roj cholesterol"?

Kua polyphenolsTsis yog ib qho sib xyaw ua ke, tab sis cov txheej txheem nyuaj uas muaj catechins, anthocyanins, chlorogenic acid, thiab hauv paus bark glycosides. Raws li ntau cov ntaub ntawv tshuaj xyuas, molecular mechanism ntawm kev tswj cov roj cholesterol feem ntau suav nrog cov hauv qab no:

1. inhibit qhov kev ua ntawm cov roj cholesterol ester hloov protein (CETP)
Apple polyphenols tuaj yeem txo qhov sib piv ntawm cov roj lipoprotein ceev (tsis yog-HDL-C) kom tsawg-density lipoprotein cholesterol (LDL-C) los ntawm inhibiting plasma CETP. kev ua si. Cov txheej txheem no tau raug lees paub nyob rau hauv cov qauv tsiaj, tab sis tseem tsis muaj sijhawm ntev -cov ntaub ntawv tshawb fawb txog cov neeg noj qab haus huv.

2. Upregulation ntawm peroxisome proliferator-activated receptor alpha (PPAR alpha) qhia
Nyob rau hauv daim siab cell qauv, kua polyphenol extract muaj peev xwm ho upregulate PPAR qhia, txhim khu fatty acid oxidation, thiab indirectly txo cov cholesterol synthesis substrates nyob rau hauv daim siab. Txoj hauv kev no muab lub hauv paus molecular biology piav qhia nws cov lipid- txo qis.

3. Kev tswj lub plab microbiota bile acid axis
Cov tshuaj polyphenolic tuaj yeem inhibit endogenous cholesterol synthesis los ntawm kev hloov cov qauv ntawm plab microbiota, txhawb cov kua tsib kua qaub tawm, thiab ua kom lub cev tsis zoo ntawm lub plab hnyuv ncig. Cov txheej txheem no tau tshawb nrhiav ntau zaus hauv kev tshawb fawb tom qab xyoo 2022, tab sis qhov tseeb koob tshuaj -cov qauv kev sib raug zoo tseem tsis tau tsim.

Cov ntsiab lus tseem ceeb: Txawm hais tias kev tshawb fawb txog kev siv tshuab tau nce zuj zus hauv - qhov tob, cov pov thawj uas twb muaj lawm feem ntau tseem nyob hauv qib ntawm kev sim tsiaj thiab kev tshawb fawb hauv vitro.
Nws tau hais meej meej tias feem ntau ntawm cov txheej txheem kev tshawb fawb tau luam tawm nyob ib ncig ntawm 2005, thiab cov ntaub ntawv ua tiav metadata ntawm siab - cuam tshuam tib neeg randomized tswj kev sim (RCTs) suav nrog hauv Tuam Tshoj National Knowledge Infrastructure (CNKI) nruab nrab ntawm 2020 thiab 2023 tseem tsis tau tshaj tawm rau pej xeem retrieves, qhov kev thov loj tshaj plaws.

1. Cov khoom tsim
Cov khoom noj xws li "Kua PolyphenolsPressed Candy" thiab "Apple Vinegar Soft Capsules" dominate the market. Los ntawm kev tsim cov qauv nrog kev pom zoo txhua hnub ntawm ntau dua lossis sib npaug ntawm 500mg polyphenols, kev kawm ntawm cov neeg siv khoom tau ua tiav nrog kev ntxhib los mos "zoo thiab ntsiag to".

2. Muaj nuj nqi thov dawb paug
Raws li qhov kawg ntawm 2023, tsis muaj daim ntawv pov thawj sau npe nrog "txiv apple extract"raws li cov khoom siv tseem ceeb thiab tau pom zoo "kev pabcuam lipid- txo qis" muaj nuj nqi tau pom nyob rau hauv cov khoom noj khoom haus kev noj qab haus huv ntawm Lub Xeev Kev Tswj Xyuas Kev Tswj Xyuas Kev Lag Luam. Tsuas yog cov khoom lag luam cuam tshuam yog Tianting ® Apple calcium pyruvate ntsiav tshuaj muaj lub luag haujlwm ntawm "qhov hnyav", thiab cov kua extract tsuas yog cov khoom siv hauv cov mis, nrog rau tus nqi ntxiv ntawm tsawg dua 10%.

3. R ​​& D peev sib txawv
R&D peev hauv kev lag luam yog tsom rau kev ua kom zoo dua cov txheej txheem rho tawm (xws li supercritical CO₂ extraction thiab enzyme- pab rho tawm), tab sis tsis muaj peev txheej hauv RCT kev tshawb fawb rau cov neeg tshwj xeeb (xws li mob hypercholesterolemia). Txoj kev tshawb fawb 2020 Koutsos tau hais yog RCT, tab sis cov ntsiab lus yog tag nrho cov txiv hmab txiv ntoo tau txais "ob txiv apples ib hnub", uas tsis yog cov qauv tsim tawm thiab tsis tuaj yeem xa ncaj qha mus rau cov ntawv thov khoom.

Xaus
Qhov scientific hypothesis ntawdpolyphenols ntawm txiv applestuaj yeem txo cov roj cholesterol muaj qhov tsim nyog molecular mechanism thiab cov khoom siv raw khoom txaus. Los ntawm 2021 txog 2023, Tuam Tshoj cov kua txiv hmab txiv ntoo yuav nyob ruaj khov nyob rau hauv thaj tsam ntawm 46 lab rau 50 lab tons, thiab cov khoom siv raw yuav lav.

Tus yuam sij rau txoj kev loj hlob ntawm kev lag luam nyob rau hauv 3-5 xyoo tom ntej no yog nyob rau hauv seb ib lub lag luam puas tuaj yeem ua tus thawj coj hauv kev ua tiav RCT kev tshawb fawb uas ua tau raws li tus yam ntxwv ntawm cov pej xeem Suav thiab xa cov ntaub ntawv raw khoom tshiab. Nyob rau hauv cov txheej txheem no, nws yog ib qho tsim nyog yuav tsum tau ua raws li cov kab hauv qab ntawm kev tshawb fawb authenticity, tsis txhob exaggerating epidemiological koom haum raws li cov teeb meem tshwm sim, thiab tag nrho siv lub scale kom zoo dua ntawm Tuam Tshoj tus.apple kev lag luamlos txhawb kev hloov pauv ntawm kev rho tawm los ntawm "qis-tus nqi raw khoom" mus rau "siab-tus nqi ua haujlwm". Yog xav paub ntxiv txogpolyphenols ntawm txiv apples, txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn; +86-138-0919-0407)

Kev siv

[1] Kua: ib lub txiv apple ib hnub, tseem ua rau tus kws kho mob mus?. Torsten Bohn et al. [2020]

[2] P. Knekt, J., Kumpulainen et al. "Kev noj cov flavonoid thiab kev pheej hmoo ntawm cov kab mob ntev." American Journal of Clinical Nutrition (2002). [2002-09-01]

[3] Y. Pathak. "Phau ntawv ntawm Nutraceuticals Volume II: Scale-Up, Processing thiab Automation." (2011). [2011-05-16]

[4] C. Bondonno, Xingbin Yang et al. "Flavonoid-nplua nuj txiv apples thiab nitrate-nplua nuj spinach augment nitric oxide raws li txoj cai thiab txhim kho endothelial muaj nuj nqi nyob rau hauv cov txiv neej noj qab haus huv thiab cov poj niam: ib tug randomized tswj mus sim.." Dawb radical biology & tshuaj (2012). [2012]