SPINS tshaj tawm 25 cov khoom siv kub kub hauv Asmeskas kev ua lag luam hauv xyoo 2022 hauv kev muag khoom ntawm ntuj fortification channel. Ntawm lawv, kev muag khoom ntawm ib qho khoom siv raw tau nce 33 feem pua (2021, 13.66 lab US las / 2022, 18.17 lab US las), cov khoom siv raw yog quercetin. Los ntawm 2021 txog 2020, nws qhov kev muag khoom loj hlob mus txog 133.6 feem pua, uas yog nrov heev hauv Asmeskas kev lag luam.
1. Dab tsi yog quercetin
2. Dawb radical "scavenger", quercetin muaj peev xwm super antioxidant
3. Quercetin-nplua nuj daim ntawv thov scenarios
1. quercetin yog dab tsi?
Quercetin yog ib qho flavonoid uas tau muab cais ua flavonol (ib ntawm rau lub subclasses ntawm flavonoid compounds). Quercetin muaj dav hauv zaub thiab txiv hmab txiv ntoo, xws li txiv apples, berries, txiv lws suav, txiv hmab txiv ntoo, dos, thiab lwm yam. Tsis tas li ntawd, nws kuj muaj nyob rau hauv cov nroj tsuag tshuaj, xws li ginkgo biloba thiab forsythia.
Quercetin, nws lub npe yog muab los ntawm quercetin thiab tau siv txij li xyoo 1857, yog ib qho tshwm sim tshwm sim polar auxin thauj inhibitor. Quercetin yog ib yam ntawm aglycone, lub ci daj koob siv lead ua, tag nrho insoluble nyob rau hauv dej txias, tsis yooj yim soluble nyob rau hauv dej kub, soluble heev nyob rau hauv cawv thiab lipids. Quercetin glycosides yog tsim los ntawm kev tshem tawm ib qho ntawm OH pawg (feem ntau nyob rau hauv txoj hauj lwm 3) nrog ib pawg qab zib (qab zib xws li qabzib, rhamnose, lossis rutinose). Cov pab pawg qab zib txuas nrog tuaj yeem hloov pauv solubility, nqus, thiab hauv vivo cuam tshuam.
Quercetin structural formula
Hauv xyoo 2010, quercetin tau dhau FDA daim ntawv pov thawj GRAS thiab tuaj yeem siv rau hauv dej haus, khoom noj khoom haus, nplej zom, cov txiv hmab txiv ntoo thiab kua txiv hmab txiv ntoo, thiab cov gummies, nrog rau cov ntsiab lus siab tshaj plaws ntawm 500 mg ib zaug. Hauv Nyiv thiab Kaus Lim Kauslim, quercetin yog siv los ua zaub mov ntxiv.
Tam sim no, nyob rau hauv peb lub teb chaws, quercetin tsis tuaj yeem siv rau hauv cov khoom noj khoom haus thiab kev noj qab haus huv. Xyoo 2021, kuv lub tebchaws tau pom zoo dihydro quercetin ua cov khoom noj tshiab, uas tuaj yeem siv rau hauv cov dej haus (tsawg dua lossis sib npaug li 20 mg / L), fermented mis nyuj thiab flavored fermented mis nyuj (tsawg dua lossis sib npaug li 20 mg / kg) , cocoa khoom, chocolate thiab chocolate khoom (tsawg dua los yog sib npaug rau 70 mg / kg). Dihydroquercetin tseem yog flavonol compound, uas muaj ob lub atoms hydrogen ntau dua li quercetin.
2. Dawb radical "scavenger", quercetin muaj peev xwm super antioxidant
Dawb radicals yog tsim los ntawm lub cev thaum lub sij hawm metabolism thiab yog ib qho ntawm cov ua rau ntau yam kab mob. Lawv tuaj yeem ua rau lub cev puas tsuaj, thiab cov noob hloov pauv, ua kom lub cev laus zuj zus, thiab ua rau mob plawv, mob siab, mob ntshav qab zib thiab lwm yam kab mob. Cov kev tshawb fawb tau pom tias quercetin yog ib qho zoo tshaj plaws dawb radical scavengers hauv tsev neeg flavonoid.
Lub peev xwm antioxidant ntawm quercetin yog qhov muaj txiaj ntsig zoo nrog nws cov concentration, thiab nws cov peev xwm antioxidant feem ntau yog tshwm sim los ntawm cov teebmeem ntawm glutathione (GSH), enzyme kev ua, teeb liab txoj hauv kev thiab cov pa oxygen reactive (ROS).
Tsiaj txhu thiab cov kev tshawb fawb ntawm tes tau pom tias quercetin induces GSH synthesis thiab kev kho nrog quercetin nce GSH qib hauv lub raum ischemia / reperfusion (I / R); tuaj yeem nce superoxide dismutase (SOD) thiab hydrogen peroxide Enzyme (CAT) qib, thiab txo cov qib malondialdehyde (MDA) tom qab lipopolysaccharide (LPS) induction; tuaj yeem txhim kho lub cev cov tshuaj tiv thaiv kab mob antioxidant, kho tus txha caj qaum raug mob, atherosclerosis, txhuas lossis cadmium lom thiab lwm yam kev puas tsuaj; tuaj yeem Scavening ROS los tiv thaiv oxidative puas tsuaj, xws li ua pa puas, hluav taws xob vim UV daim tawv nqaij puas tsuaj, thiab lwm yam, txhua tus qhia tau hais tias quercetin tuaj yeem txhim kho cov kab mob antioxidant.
3. Quercetin-nplua nuj daim ntawv thov scenarios
1) tswj cov ntshav siab
Quercetin tau pom tias tswj cov ntshav siab los ntawm kev hloov ntau yam kev tswj ntshav siab, xws li vascular ua raws thiab kev ua haujlwm, tag nrho cov ntshav ntim nyob ntawm lub cev ntim dej, lub paj hlwb tsis muaj zog, thiab renin-angiotensin system. Tsis tas li ntawd, quercetin kuj muaj cov kev cai tshwj xeeb ntawm EnaC (epithelial sodium ion channel) cov noob qhia, uas yog los ntawm kev ua kom NKCC1 (Na plus -K plus -2C− cotransporter 1) ntawm [Cl -] c ( cell-mediated los ntawm kev tswj ntawm solute Cl- concentration).
Ib qho kev tshawb fawb randomized, ob-dig muag, tshuaj placebo-tswj, crossover txoj kev tshawb fawb pom tau tias ib hnub noj 730 mg quercetin rau 4 lub lis piam txo cov ntshav siab systolic thiab diastolic hauv cov neeg mob ntshav siab theem 1, tab sis tsis muaj kev cuam tshuam rau systolic lossis diastolic ntshav siab hauv prehypertensive. cov neeg mob. Diastolic ntshav siab tsis cuam tshuam. Kev tshawb fawb hauv cov neeg uas muaj cov kab mob metabolic pom tias noj 150 mg ntawm quercetin txhua hnub rau 5 lub lis piam txo cov ntshav siab.
2) Kev tiv thaiv kab mob
Hauv vivo (cell) thiab hauv vivo (tsiaj) kev sim tau pom tias quercetin muaj kev tiv thaiv kab mob. Kev sim nas pom tau tias quercetin tuaj yeem tiv thaiv hluav taws xob los ntawm kev ua kom cytokine secretion, thiab quercetin kuj muaj cov tshuaj tiv thaiv isoproterenol-induced myocardial oxidative puas tsuaj thiab kev tiv thaiv kab mob, uas zoo ib yam nrog Antioxidant kev ua ntawm quercetin.
3) Tshem tawm kev ua xua
Quercetin tuaj yeem inhibit qhov tsim ntawm histamine thiab pro-inflammatory mediators. Cov kev tshawb fawb tau pom tias nws muaj peev xwm txo tau cov mob hawb pob xws li eosinophil thiab neutrophil recruitment, bronchial epithelial cell activation, collagen thiab mucus ntau lawm, thiab cov pa cua hyperresponsiveness. Nws tuaj yeem cuam tshuam kev tsim cov periostin thiab periostin-induced eosinophil chemoattractant, yog li txhim kho cov tsos mob ntawm kev tsis haum rhinitis.
4) Kev Noj Qab Haus Huv
Quercetin tuaj yeem ua kom cov collagen thiab fibronectin nce ntxiv hauv lub cev. Hauv kev tshawb fawb hauv chaw soj nstuam, quercetin txo qis qhov mob ntawm cov neeg mob caj dab, thiab txoj kev tshawb fawb pom tias hloov mus rau cov khoom noj uas muaj flavonoids ua rau cov tsos mob zoo dua qub rau cov neeg mob rheumatoid.
5) Tsawg uric acid
Ib qho kev sim hauv nas nrog hyperuricemia pom tias tom qab kev kho mob nrog quercetin, xanthine oxidase kev ua haujlwm raug cuam tshuam, oxidative kev ntxhov siab raug txo, thiab hyperuricemia tau txhim kho. Cov txheej txheem yuav yog tias quercetin txo cov ntshav uric acid los ntawm inhibiting cov haujlwm ntawm xanthine oxidase thiab adenosine deaminase, yog li txo cov ntshav uric acid.
Appchem Ntshiab Quercetin Powder
