Puas yog kua (apple polyphenol) zoo rau kev mob caj dab?

Kev mob caj dab, tshwj xeeb tshaj yog osteoarthritis (OA) thiab mob caj dab rheumatoid (RA), yog ib qho ua rau mob thiab kev tsis taus thoob ntiaj teb. Nrog rau kev laus zuj zus ntawm cov pej xeem thiab kev txaus siab ntawm cov neeg siv khoom hauv cov kev daws teeb meem kev noj qab haus huv, kev siv cov nroj tsuag rho tawm hauv kev sib koom ua ke kev noj qab haus huv tau nyiam ntau yam. Kua, raws li ib tug ntawm cov feem ntau txiv hmab txiv ntoo nyob rau hauv lub neej txhua hnub, yog maj mam nkag mus rau hauv lub teb ntawm kev tshawb fawb thiab kev lag luam vim nws muaj zog antioxidant thiab anti- muaj peev xwm inflammatory, uas yog nplua nuj nyob rau hauvpolyphenols ntawm txiv apples.

Kev mob caj dab tsis yog ib yam kab mob xwb, tab sis ib lo lus dav dav uas suav nrog ntau dua 100 hom kab mob sib koom ua ke.

1. Hom:Ntawm lawv, osteoarthritis (OA) feem ntau tshwm sim los ntawm kev hloov pauv thiab hnav cov pob txha pob txha, thaum mob caj dab rheumatoid (RA) yog cov kab mob mob ntev uas cuam tshuam nrog autoimmune system, uas tuaj yeem ua rau kev sib koom ua ke thiab kev ua haujlwm tsis zoo.

2. Txoj kev: Cov kev kho mob ib txwm muaj, xws li nonsteroidal anti-cov tshuaj tiv thaiv kab mob (NSAIDs) thiab glucocorticoids, txawm hais tias muaj txiaj ntsig zoo hauv kev txo cov tsos mob, kev siv sijhawm ntev - tuaj yeem ua rau mob plab, mob plawv, thiab lwm yam kev mob tshwm sim.

Polyphenols, dav muaj nyob rau hauv txiv hmab txiv ntoo, zaub, tshuaj yej, thiab lwm yam nroj tsuag, tau nyiam ntau xim vim lawv cov antioxidant thiab tiv thaiv - inflammatory zog. Kev tshuaj xyuas zoo tau qhia tias kev noj zaub mov polyphenols, xws li cov tshuaj yej ntsuab, pomegranate, turmeric, thiab lwm yam, muaj txiaj ntsig zoo rau kev txo qis kev mob thiab cov tsos mob ntawm mob caj dab rheumatoid. Hauv cov ntsiab lus no, cov kua txiv hmab txiv ntoo puas tuaj yeem muaj ntau hauv cov txiv apples, dhau los ua "tus nees tsaus" hauv kev sib koom ua lag luam noj qab haus huv?

Kua polyphenolsTsis yog ib qho sib xyaw ua ke, tab sis cov sib xyaw ua ke ntawm ntau yam phenolic, feem ntau suav nrog anthocyanins (Procyanidins), flavononls (xws li quercetin thiab nws glycosides), phenolic acids (xws li chlorogenic acid), thiab dihydrochalcones. Cov khoom xyaw nquag ua haujlwm ua ke kom muaj txiaj ntsig zoo rau cov kua txiv hmab txiv ntoo polyphenols nrog kev ua haujlwm lom neeg muaj zog.

Raws li kev nkag siab dav dav ntawm kev tiv thaiv kev tiv thaiv - cov txheej txheem inflammatory ntawm cov tshuaj polyphenolic, cov kev tshawb fawb hauv zej zog cov kev xav txog kev cuam tshuam ntawm apple polyphenols hauv kev mob caj dab feem ntau tsom rau cov hauv qab no:

• Antioxidant nyhuv:Thaum lub sij hawm tus txheej txheem ntawm kev mob caj dab, ib tug loj npaum li cas ntawm reactive oxygen hom (ROS) yog tsim nyob rau hauv lub sib koom kab noj hniav, ua rau oxidative kev nyuaj siab, exacerbating chondrocyte apoptosis thiab matrix degradation. Apple polyphenols, tshwj xeeb tshaj yog anthocyanins, tau raug pov thawj tias muaj peev xwm tshem tawm cov dawb radicals zoo heev thiab theoretically tuaj yeem txo oxidative puas tsuaj rau cov ntaub so ntswg.
• Kev tiv thaiv -inflammatory mechanism:Kev mob ntev yog qhov txuas tseem ceeb uas tsav cov txheej txheem pathological ntawm kev mob caj dab. Kev tshawb fawb tau pom tias ntau yam polyphenols tuaj yeem ua rau lawv cov teebmeem los ntawm inhibiting qhov tseem ceeb inflammatory signaling pathways, xws li nuclear factor kappa B (NF-κB) thiab mitogen-activated protein kinase (MAPK) txoj kev. Yog li, cov kua txiv polyphenols tuaj yeem cuam tshuam kev sib koom ua ke ntawm qhov chaw los ntawm kev tswj cov txheej txheem no.

  

  

Txawm tiaspolyphenols ntawm txiv applestheoretically muaj lub peev xwm zoo los txo kev mob caj dab, tam sim no muaj cov txheeb ze tsis muaj cov ntaub ntawv tshawb fawb thiab cov ntaub ntawv tshawb fawb ncaj qha ncaj qha rau lawv daim ntawv thov hauv kev mob caj dab. Txawm hais tias muaj qee qhov kev tshawb fawb soj ntsuam txog kev ua tau zoo ntawm lwm cov polyphenols (xws li curcumin, ntsuab tshuaj yej polyphenols, thiab pomegranate extract) hauv kev kho mob caj dab. Muaj txawm tias muaj kev tshuaj xyuas thiab meta- kev tshuaj xyuas ntawm qhov cuam tshuam ntawm kev noj haus polyphenols ntawm rheumatoid mob caj dab. Tab sis cov txiaj ntsig ntawm cov kev tshawb fawb no tsis tuaj yeem cuam tshuam ncaj qha raupolyphenols ntawm txiv apples. Polyphenols los ntawm ntau qhov chaw muaj cov qauv tshuaj sib txawv, bioavailability, thiab cov txheej txheem ntawm kev ua.

Rov qab mus rau lo lus nug qub: "Yogpolyphenols ntawm txiv applesRaws li cov pov thawj scientific tam sim no, peb cov lus teb yog: theoretically ua tau thiab muaj peev xwm zoo, tab sis cov ntaub ntawv pov thawj kho mob tsis txaus.Rau cov kws kho mob hauv kev lag luam cog extract, qhov no txhais tau hais tias cov kua polyphenols yog lub lag luam xiav dej hiav txwv uas muaj lub cib fim, tab sis kuj nrog cov teeb meem loj hauv kev sib koom tes kev noj qab haus huv.

Yog xav paub ntxiv txogpolyphenols ntawm txiv apples, txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn; +86-138-0919-0407)

Kev siv

[1] Pov Thawj Kev Noj Qab Haus Huv 7: Tsib Hlis 2025 - Polyphenols. British Association for Nutrition & Lifestyle Medicine (BANT). [2025-05]
[2] Kev Txhim Kho Tsis ntev los no hauv Kev Tshawb Fawb Osteoarthritis: Txoj Kev Kho Mob Tshiab thiab Lub Luag Haujlwm ntawm Polyphenols thiab Nanotechnology. Humberto Vélez-Slimani et al. [2025-09-13]
[3] Hani MJ Khojah, Sameh A. Ahmed et al. "Resveratrol ua ib qho kev kho mob zoo hauv kev tswj cov kab mob rheumatoid: kev tshawb fawb soj ntsuam." Clinical Rheumatology (2018). [2018-04-03]
[4] M. Rosillo, M. Alcaraz et al. "Anti-kev mob thiab kev tiv thaiv kev sib koom ua ke ntawm kev ntxiv- nkauj xwb txiv roj roj- roj polyphenol extract hauv kev sim mob caj dab." Phau ntawv Journal of Nutritional Biochemistry (2014). [2014-12-01]
[5] M. Neog, Samuel Joshua Pragasam et al. "p-Coumaric acid, ib qho kev noj haus polyphenol, ameliorates o thiab curtails pob txha thiab pob txha erosion nyob rau hauv cov kab mob rheumatoid nas qauv." BioFactors (2017)[2017-09-10]