Cov txiv apples puas tshem tawm cov co toxins?

Raws li lub ntiaj teb loj tshaj plaws temperate txiv hmab txiv ntoo qoob loo, txiv hmab txiv ntoo extracts (tshwj xeeb tshaj yogtxiv apples polyphenols, pectin, thiabflavonoids) tuav txoj haujlwm tseem ceeb hauv kev ua haujlwm ntawm cov khoom noj khoom haus thiab cov khoom noj khoom haus. Txawm li cas los xij, puas muaj lub hauv paus rau kev thov tias "txiv apples tuaj yeem tshem tawm cov co toxins ntawm lub cev" hauv cov ntaub ntawv tshawb fawb thiab cov lus qhia txog kev noj qab haus huv?

1.1 Kev Tshawb Fawb Txog Kev Siv Lub Siab Detoxification Enzyme System (Phase I & Phase II)
Kev ua haujlwm detoxification ntawm tib neeg lub cev feem ntau yog nyob ntawm cytochrome P450 enzyme system (CYP450, teej tug mus rau Phase I cov tshuaj tiv thaiv) thiab khi enzyme system (Phase II cov tshuaj tiv thaiv) ntawm lub siab, suav nrog glutathione S-}transferase (GST) thiab UDP glucuronosyltransferase (UGT). Cov enzymes no hloov cov tshuaj endogenous thiab exogenous co toxins mus rau hauv cov dej tawm tau yooj yim -soluble metabolites los ntawm oxidation, hydrolysis, thiab khi cov tshuaj tiv thaiv.

1.2 Induction ntawm detoxification enzymes los ntawm kua polyphenols: tsiaj sim pov thawj
Raws li cov txiaj ntsig tshawb fawb, kev tswj hwm cov txiaj ntsig ntawmKua Polyphenolsnyob rau hauv detoxification enzyme system feem ntau tseem nyob rau theem ntawm kev sim hauv vitro cell thiab cov qauv tsiaj. Ib txoj kev tshawb fawb luam tawm hauv Food&Function hauv 2015 tau pom tias cov kua polyphenol extract muaj kev tiv thaiv ntawm cov pa roj carbon tetrachloride (CCl ₄) - induced siab raug mob hauv cov nas, uas tej zaum yuav cuam tshuam rau kev ua kom cov Nrf2/ARE signaling pathway, yog li ua rau kom cov mRNA qhia theem ntawm cov enzymes theem II (detox). Lwm qhov kev tshawb fawb xyoo 2010 kuj tau qhia tiastxiv apples polyphenolstuaj yeem ua rau GST thiab UGT kev ua haujlwm hauv cov qog nqaij hlav hauv plab, tab sis tsis tau muab cov ntaub ntawv ntau ntawm daim siab.

Quercetin, lub ntsiab flavonoid compound nyob rau hauv txiv apples, tau pom tias induce UGT1A1 qhia nyob rau hauv Caco-2 plab hnyuv epithelial hlwb. Txawm li cas los xij, cov kev tshawb fawb no muaj ob qhov kev txwv loj: ua ntej, qhov concentration ntawm quercetin siv hauv kev sim ntawm tes (feem ntau yog 50-200 μ M) ntau dua li qhov siab tshaj plaws plasma concentration tom qab noj txiv apples txhua hnub (li 0.5-1 μ M); Qhov thib ob, tsis muaj kev cuam tshuam kev tshawb fawb hauv Suav cov pej xeem nyob nruab nrab ntawm 2020 thiab 2024 tau lees paub tias kev noj cov txiv apples tsis tu ncua ua rau muaj qhov nce ntxiv ntawm UGT enzyme ua haujlwm hauv daim siab lossis cov hnyuv.

2.1 Functional Food Development: Cov pov thawj-raws li Kev Pabcuam Kev Noj Qab Haus Huv
Txawm hais tias qhov kev thov ntawm "detoxification" tsis muaj pov thawj, kua extract muaj cov khoom siv tshawb fawb hauv cov lus qhia hauv qab no:

• Antioxidant: Tus nqi ORAC (oxygen dawb radical absorption muaj peev xwm) ntawm cov kua polyphenols yog 2670 μ mol TE / 100g, thiab nws cov nyhuv hauv kev txo qis oxidative stress markers (MDA) tau raug lees paub hauv ntau qhov kev sim tib neeg.
• Kev noj qab haus huv hauv plab: Pectin, raws li prebiotic, tuaj yeem txhawb kev loj hlob ntawm bifidobacteria thiab txhim kho cem quav. Ib txoj kev tshawb fawb Suav xyoo 2022 tau lees paub tias kev noj txhua hnub ntawm 10 grams ntawm cov kua pectin ua rau lub sijhawm ua haujlwm ntawm cov neeg koom nrog los ntawm 18% (p.<0.05) after 4 weeks.
• Kev tswj cov ntshav qabzib:PhloridzinHauv cov txiv apples tuaj yeem ua rau qeeb cov piam thaj nqus los ntawm inhibiting SGLT1/2 transporter. Kev soj ntsuam randomized hauv 2023 tau qhia tias kev noj cov txiv apples ua ntej noj mov tuaj yeem txo qhov chaw hauv qab 2 teev tom qab cov ntshav qabzib nkhaus los ntawm 23%.

Cov tuam txhab cog qoob loo yuav tsum tsom mus rau cov ntsiab lus muaj txiaj ntsig thiab txheeb xyuas cov txiaj ntsig tau hais los saum toj no, thiab siv cov lus hais xws li "pab nrog antioxidant" thiab "ua kom cov plab hnyuv ua haujlwm zoo" hauv cov ntawv cim khoom, zam cov ntsiab lus tsis meej xws li "detoxification" thiab "purification".

Yog xav paub ntxiv txogtxiv apples polyphenols, txuas nrog Serrisha los ntawm APPCHEM. (Email:cwj@appchem.cn; +86-138-0919-0407)
Kev siv

[1]Pectin hauv Metabolic Kab Mob Siab. Wanchao Hu et al[2023]
[2] Li YJ, Li YJ, et al. "Hepatoprotective teebmeem ntawm apple polyphenols ntawm CCl4-induced mob siab puas siab puas ntsws nyob rau hauv nas.." Phau ntawv Journal of Agriculture thiab zaub mov chemistry (2010).[2010-04-23]
[3] Kev soj ntsuam kev pheej hmoo thiab kev saib xyuas ntawm dinotefuran thiab nws cov metabolites rau Suav noj txiv apples. Yu. [2017-09-26]

[4] Zhang Xu, M. Zeng et al. "Puas yog ib lub txiv apples ib hnub kom tshem tau cov kab mob? Cov pov thawj thiab cov txheej txheem ntawm kev ua." Food Science & Nutrition (2023). [2023-06-20]