Thermopsis lasnolata r.br extract; Cytisine HPLC98% HMOOV 485-35-8

Cytisine(Kuj tseem hu ua Cytisinicline; Cas Tsis muaj . 485-35-8}}) yog qhov sib txuas hauv cov nroj tsuag ntawm cov genusThermopsisHauv tsev neeg legume (leguminosae). Nws yog lub ntuj alkaloid muab rho tawm cov nroj tsuag leguminous._[1-3]Cov nroj tsuag no muaj ntau yam alkaloids, ntawm cov txheeb ze cov ntsiab lus ntawm quercetin yog qhov siab tshaj plaws, suav nyiaj rau ib nrab ntawm tag nrho cov ntsiab lus alkaloid. Chrysophylline muaj cov tshuaj muaj txiaj ntsig zoo thiab yog ib qho khoom siv tseem ceeb rau kev lag luam kws tshuaj. Jinquaehua alkaloid yog ib feem ntawm 4 2 cov txiaj ntsig zoo rau nws, uas yog cov tshuaj ntxuav pa taws, tshwj xeeb yog nws cov tshuaj luam yeeb.

Cytisineyog feem ntau muab tau los ntawm tsob ntoo leguminousThermopsis lanceolata R. Br., uas siv los ua tshuaj ntsuab ntawm cov tshuaj ntsuab thiab feem ntau hu ua "tswv yim cov taum" (Muma taum). Nws tseem yog lub npe hu ua daj -} browed iab taum taum, hmuv- leaded tsiaj cassia noob, lossis taum iab.

Tus tswv yug yaj loj hlob ntawm Serorebank Grasslands, Dunes, txoj kev, thiab chaw ua teb. Nws tau faib rau Northeast, North, thiab sab qaum teb, Hennia, Shaanxi, Shaanxi, Xinjian, Xizjian, thiab lwm yam xeev thiab cheeb tsam.

Tag nrho cov nyom ntawm Muma taum muaj cov alkaloids muaj alkaloids muaj alkaloids nyob ntawm 0.5% mus rau 3%, ntawm cov ntsiab lus ntawm cov cuab yeej noob caj noob ces yog tag nrho cov alkaloids. Cov ntsiab lus alkaloid hauv cov noob yog qhov tseem ceeb, ncav cuag li 5%._[5]Nws lub ntsiab alkaloid Cheebtsam yogcytisine, Ntxiv rau Berberine, Sophocarpine, Stinky taum alkaloid, angline clawer taum, lupine, rhododendron alkaloid, thiab Huanghua Amine. Cov nplooj tseem muaj me me ntawm flavonoids._[6] 

Cov kev rho tawm ntawmcytisineSiv ntau cov tswv yim tsim los ua kom tiav cov txiaj ntsig siab thiab kev coj dawb huv. Cov txheej txheem rho tawm cov txheej txheem suav nrog: cov khoom siv raw → crushing → Shalicography Refratogration → surrata gel surromatogy → surringallization → qhuav →

• Cov txheej txheem ib txwm muaj thiab crystallization txoj kev: siv Muma taum ua cov khoom siv raw, tom qab kev sib txuas nrog ethanol, lim thiab ua ke kom tau txais cov extract; Kho cov ph ntawm cov extract nrog sulfuric acid thiab extract nws nrog chloroform kom tshem tawm cov organic impurities; Kho cov ph ntawm cov txheej txheej nrog sodium hydrocide kom cov alkaloid dawb, thiab tom qab ntawd rho tawm tag nrho cov alkaloids nrog chloroform; Dissolve thiab txias tag nrho alkaloids hauv acetone kom tau txais cov muaju crude; Cov muaju crude tau hais hauv Ethyl acyled nyob rau hauv ethyl acetate thiab acetone, txias thiab recrystallized kom tau siab {{purity cytisine.

Featuring cov kauj ruam yooj yim thiab kev ua haujlwm yooj yim, cov qauv no muab cov txiaj ntsig zoo, cov txiaj ntsig sai sai, muaj txiaj ntsig zoo tshaj 98%.

• Macroporous Resin Purification Txuj Ci: Cov qauv no siv 40-cytisine.
  Dissolve qhov kev tshawb xyuas hauv cov kua a acidified aqueous (ph 1-3) thiab lim. Kho cov pH rau 7.5,5, adsorb mus rau hauv thaj chaw macropore resin, thiab yaug nrog dej kom txog thaum lub effluent khiav nruab nrab. Tom qab ntawd elute lub hom phiaj sib txuas siv siv 60-90% ethanol. Tus Eluent yog concentrated nyob rau hauv siab txo siab kom tau txais kua extract. Thaum kawg, Acetone tau ntxiv thiab ua kom sov kom yaj cov muaju 2-3 lub sij hawm. Lub muaju tau lim thiab qhuav ntawm qhov kub kom tau txaiscytisineCov. Cov qauv no muaj cov tshuaj tiv thaiv ntau dua, yuav tsum muaj tsawg cov tshuaj lom neeg lom zem, thiab yog ib puag ncig zoo dua._[10]

Raws li cov ntaub ntawv, tus tswv yug yaj lub caj pas yog tsob ntoo lom, thiab nws cov khoom siv tseem ceeb yogcytisineCov. Cov kev tshawb fawb tsis ntev los no qhia tau hais tias cytisine alkaloids nthuav tawm ntau yam cuam tshuam cov khoom siv hluav taws xob, thiab cov tshuaj tiv thaiv ntshav, thiab cov tshwj xeeb}} mob cancer cov khoom._[6] 

• Core Daim Ntawv Thov: Kev Pab Cuam Tshuam Kev Haus luam yeeb

Qhov zoo tshaj plaws -} paub thiab muaj kev tshawb xyuas ntau yam ntawmcytisineyog kev sib tw kev pab txiav luam yeeb.

051 Mechanism ntawm Kev Ua:
Ib nrab agonist:Cytisinetuaj yeem xaiv khi nrog lub siab muaj zog rau 4 thiab 2 neuronal nicotinic acetylcholine recetors (ib nrab ntawm kev txiav luam yeeb thaum muaj kev ntxhov siab, thiab kev nqhis dej haus luam yeeb._[6] 
Cov txiaj ntsig ntawm txoj kev tshawb fawb qhia tias "kev haus luam yeeb ua raucytisineyog zoo dua rau kev siv tshuaj luam yeeb tam sim no siv tau los txhawb kev haus luam yeeb hauv ntiaj teb ", thiab nws yuav tau ua luam yeebcytisineMuaj ib tug -} xyoo haus luam yeeb ua tau zoo txog li 22%, thiab tau txais kev txhim kho kev txhim kho haus luam yeeb._[7]

Ntau qhov kev sim tshuaj thiab kev ntsuam xyuas ua kom pom tseeb tau ua kom pom kev ua tau zoo ntawmcytisinehauv kev txhawb nqa kev txiav luam yeeb. Qhov loj {- teev cov kws ntsuam xyuas kev sim siab (}} Piv nrog rau lwm qhov feem ntau siv cov tshuaj haus luam yeeb, varenocline, kev kuaj mob ntawm kev sib tw tiv thaiv 800 cov neeg haus luam yeeb tau pom tias kev ua tiav ntawm kev haus luam yeeb nrogcytisine(25-hnub chav kawm) yog 40%, uas yog sib piv rau Varenicline's (84-hnub chav kawm) kev vam meej ntawm 42%, tsis muaj qhov sib txawv ntawm 42. Qhov no qhia tau tiascytisineYuav tuaj yeem ua tiav cov cuam tshuam haus luam yeeb zoo ib yam li varenocline hauv kev kho mob luv luv._[8] 
Tus cochalrane system ntsuam xyuas qhia tau tiascytisineMuaj txiaj ntsig zoo dua li cov placebo thiab tej zaum yuav ua tau zoo li Varenicline. Khij kwv yees tias 18 txog 23 tawm ntawm txhua 100 tus neeg uas txiav luam yeeb nrogcytisinetej zaum yuav ua tiav kev txiav luam yeeb.

052 Lwm cov ntawv thov yuav thiab cov txiaj ntsig:
Neuroprotection thiab kev txhim kho kev txawj ntse: Tej zaum nws yuav muaj kev cuam tshuam ntawm kev txhim kho kev ua haujlwm hauv Alzheimer's los ntawm kev tswj hwm cov cholinergic system (tseem tab tom tshawb fawb). Kev tshawb fawb tam sim no qhia tau tiascytisineUa kom pom lub peev xwm ntawm lub sportercological hauv ntau thaj chaw, suav nrog cov kev cuam tshuam antiarhythmic, thiab leukocyte kev cuam tshuam, nrog kev ua haujlwm anticumning lav lav.
Lwm lub tebchaws tsoos: Hauv qee lub tebchaws (xws li Russia), nws kuj tseem siv los ua kev kho mob ntsws uas txuas nrog tus mob ntsws thiab cov tsis muaj peev xwm)._[9]

Hauv kev sim sim,cytisinemuaj kev thev taus zoo. Feem ntau cov kev sib raug zoo tshaj plaws suav nrog xeev siab, npau suav, thiab mob taub hau, tab sis lawv feem ntau tsis tshua muaj siab ntev thiab txo lub sijhawm. Cov kev nyuaj siab uas muaj tsawg.

• Contraindicated pej xeem

①prognant thiab lactating poj niam: nws yuav cuam tshuam rau kev txhim kho fetal lossis mis mem tes.
②cardiovascular tus neeg mob, xws li cov uas muaj angina pectoris, arrhythmia (vim muaj peev xwm ntawm cov ntshav siab thiab lub plawv dhia).
③patients nrog kev mob hlwb, xws li tus mob schizophrenia, tej zaum yuav muaj cov tsos mob.
④people uas yog ua xua rau noob caj noob.

• Kev sib cuam tshuam yeeb tshuaj

Zam txhob siv ua ke nrog cov tshuaj hauv qab no:

Kev kho mob thaum nicotine, xws li thaj ua kom zoo nkauj nicotine, tej zaum yuav ua rau muaj kev txhawb nqa thiab nce kev pheej hmoo ntawm cov kev mob tshwm sim.
Cov neeg muaj kev pheej hmoo: Lawv yuav ua rau muaj kev pheej hmoo ntawm cov kev mob neurological neurological.

Cytisine, lub ntuj alkaloid, tau muaj qhov tshwm sim zoo li kev ua luam yeeb zoo, tshuaj kho tau zoo, thiab tus nqi muaj txiaj ntsig zoo, thiab muaj nuj nqis {- ua hauj lwm zoo. Nrog rau kev paub txog kev noj qab haus huv thiab kev cog qoob loo rau kev haus luam yeeb thiab cov kev hloov kho nicotine thiab nicotine hloov kev kho mob, tshwj xeeb tshaj yog cov khoom lag luam ntawm noob caj ces thiab nws cov khoom muaj feem cuam tshuam.

	Pov thawj kev txawj ntse & thoob ntiaj teb NASDAQ -}} Sau (NASDAq: Bon) Chaw Tsim Tshuaj nrog {1} {{{}}}} Xyoo ntawm Kev Tshaj Tawm; Cov khoom tau faib rau ntau dua 100 lub teb chaws, thiab kev koom nrog hauv ntiaj teb kev nthuav dav.
	24/7 Cov Neeg Siv Khoom - Qhov Kev Pabcuam feem ntau Dedicated 4 {- tus neeg tom qab- kev muag khoom muab kev txhawb nqa tiag tiag; Kev txiav txim siab txiav txim siab mus txog kev txiav txim siab rau tag nrho cov khoom pom kev pom.
	Cov Ntawv Pov Thawj & Kev Lag Luam Kev Lag Luam 20+ Daim ntawv pov thawj: Tuam Tshoj SC Tso Cai, ISO9001 / ISO22000, KOSHER, HALAL, thiab lwm yam .; Dhau FDA unannouncated kev soj ntsuam thiab nyob rau -} chaw soj ntsuam los ntawm cov tub ceev xwm thoob ntiaj teb; {{030+ National Patents, 53 Sau npe cov cim lag luam; Tsim kom muaj 4 tus qauv thoob ntiaj teb (piv txwv li, stachyose, Apple extract); Tsim cov qauv lag luam rau sclareol / ambroxide, ua kom muaj kev lag luam nkag mus.
	End - rau -}}}}}}}}}}}}}}}}}}}}}}}}}} kawg tswj Cov khoom siv raw: kev ua tiav nrog tag nrho traceeability; Kev Tsim Kev Ntau Lawm: 100,000 - Chav Kawm Txuj Ci, TUJ-TECHNITE EXTRACTOR, Hnyav Hlau Tshem Tawm, Enzymatic Purification) Rooj Sab Laj FDA / EU Cov Qauv; Kev kuaj nruj: QC chav haujlwm ua haujlwm soj ntsuam nruj me ntsis los ntawm cov khoom siv raw los ua cov khoom tiav.
	R & D & Customization Caphabities PhD-led R&D team (>50% tuav qib siab siab) nrog txiav -} ntug cov khoom siv (piv txwv li, molecular distillation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofililation, nanofility); Cov kev cai tsim, ntim, thiab OEM daws; Cov neeg ua haujlwm hauv lub Hoobkas tau txais; Tsis muaj kev koom tes ua tub luam.
	ROCTUS RIGHT RUAJ Muaj peev xwm: {{50+ thev naus laus zis, ntau cov kab ntau lawm, cov zis txhua hnub dhau 1,000 tons; Kev xa tawm sai: 80% ntawm kev txiav txim tau xa tawm tam sim ntawd; Cov Khoom Siv Hauv Ntiaj Teb Xov Xwm (EU / Us) nrog lub qhov rooj {{1} - QHOV ROOJ MEDIMODAL thauj; Cov lus nug ua tau zoo: {{{{40+ skus hla 4 yam khoom, 1, {{{}}}}}}} tons ntawm cov lus cia ua kom tiav.
	Tus nqi sib tw Hoobkas - tus nqi ncaj qha txo cov nqi thiab cov nqi logistics. Kev Koom Tes Nrog Cov Khoom Siv Ntim thiab Logistics Cov Ntaub Ntawv Xyuas kom raug nqi -}}}} kev daws teeb meem.
	Txiav - edge Testing Lab Nruab nrog HPLC, atomic nqus spectrometers, UV spectrophottometers, thiab lwm yam. Tag nrho -} spectrum kuaj rau cov hlau hnyav, cov kab mob me, thiab ua raws nrog cov cai hauv ntiaj teb.

Daim Ntawv Tshaj Tawm Kev Ruaj Ntseg:

Peb lub tuam txhab tuaj yeem lav tias cov khoom xa tuaj yeem nyab xeeb, tsis -}}}}}}}}} kev tshaj tawm. Raws li kev caij tsheb thauj mus los, txhua yam kev poob tshwm sim los ntawm cov khoom xa los ntawm peb lub tuam txhab yuav tsum yog tus xauj los ntawm peb lub tuam txhab.

Cim npe:Cytisinicline; cytisine; Thermopsis lanceolata r.br; Kev noj nyoos, kev cai raus dej, baphitoxine, Cov chaw tsim tshuaj paus, cov chaw muag khoom, chaw tsim khoom, lag luam Wholesale, zoo tshaj plaws, tus nqi, yuav, rau kev muag khoom, ntau.

Siv:

[1] Lub koom haum ntawm Botany, Suav Academy ntawm Kev Tshawb Fawb. Atlas ntawm Suav cov nroj tsuag siab dua (ntim II) [m]. Beijing: Kev Tshawb Fawb Kev Tshawb Fawb, 1972
[2] Fu Kunjun, Zhang Zhenwan, Nws Shanbao, li Al. Muaj ntawm Tuam Tshoj [m]. Beijing Science Xovxwm, 1993.42
[3] lis Yankhan. Suav peb nyob hauv keeb kwm [m]. Beijing: Tuam Tshoj Agricultural Xovxwm, 1998
[4] Wuyong, Borijihan Geriletu. Txoj kev tshiab npaj rau kev npaj Cytisine [J]. Phau ntawv Joying of Mongolia ib txwm University (Natural Science tsab), 2004, (02): 186-187.
[5] Nej khiav, chen yihui, coj nkooj, li al. Ntxiv cov thev naus laus zis thiab cov ntsiab lus kev txiav txim siab ntawm kev ua siab huv siab cytisine [j]. Ion Txauv thiab Adsorption, 2020, 36 (02): 163-172.do2: 10.16026 / J.cnki.i,2020020163.
[6] Zhang Yi. Extraction thiab sib cais ntawm cytisine los ntawm thermopsisleg cais tawm hauv kev tshawb fawb ntawm cov txheej txheem ntau lawm [d]. Northwest University, Xi'an, Suav teb, 2014.
[7] COe JW, Brooks Pr, Vetelino mg, thiab al1varenicline: Ana4B2Nicotinic recepor agonent rau kev haus tshuaj, 2005,48 (10): 3474-3474
[8] https://www.sohu.com/a/860949386_121869527
[9] https://m.chemsrc.com/Prkoduct/7564594.html
[10] https://m.tianyancha.com/zhuanli/b42f47c100a4896859c5f84541