Thaum muaj cov ntawv ceeb toom amber Raws li tib qho kev ua txhaum rau ntuj amberegris, ambrofide synthesis yog ib zaug ua kom pom zoo zais ntawm cov ntxhiab tsw qab. Los ntawm {{2} aphthalene sulfonic acid Suav teb.
Ⅰ Cov kev coj ua hluav taws xob
Txhua yam kev lag luam ntau lawm hauv peb {- theem txoj cai ntawm "oxidation → Txo ycClization":
- Oxidation Stage: Sclareol → Sclarolide (Tseem Ceeb Nruab Nrab)
- Txo theem: Sclareolide → Sclareol Glycol
- Cyclization Theem: Lub cev qhuav dej thiab kev ua kom zoo nkauj ntawm sclareol glycol → ambroxide
Ⅱ Cov Txheej Txheem Thoob Ntiaj Teb
| Lub teb chaws | Qeb oxidation | Txheej Txheem Rov Los | Cychlization Catalyst | Tag nrho cov txiaj ntsig | Tshuav |
| Switzerland | Ozone oxidation | Lialh - lithium aluminium hydride (ether) | - naphthalene sulfonic acid | 32% | Kim, cov nplaim taws, thiab tawg |
| Teb chaws russia | Sodium dichromate oxidation | Poov tshuaj borohydride (isopropanol) | P - toluenesulfonic acid | 24.5% | Chromium -} muaj cov neeg khib nyiab, loj hauv cov khoom xa tuaj |
| Amelikas teb | Kmno₄ (poov tshuaj permanganate) ob - qib oxidation | / | / | 65% | / |
| Phiaj suav | Kmno₄ (poov tshuaj permanganate) ob - qib oxidation | Kev txo ncaj qha ntawm sclareolide + recrystallization ntawm sclareol glycol | D - camphor - -}} sulfonic acid | 42% | Lub purity ntawm kev voj voog yuav tsum tau ua kom zoo. |
* Qee cov ntaub ntawv rau Tebchaws Meskas tseem tsis tau muaj.
Ⅲ Suav teb cov txheej txheem tawg
"Kmno₄ - camphardfonic acid" tsib {{}}}}}}} theem qauv ua tiav thoob ntiaj teb peak kev ua tau zoo:
- Alkaline Oxidation: KmNo₄ / Naoh Tshuab Dhia Ob Npab
- Kev siv zog acid tsis muaj zog: ua tiav ntawm sclareolide precursor kev tsim kho hauv cov acetic acid nruab nrab
- So₂ (sulfur dioxide) txo: cuv los ntawm {- Cov khoom mno₂ los txhim kho kev coj dawb huv
- Saponification lub cev qhuav dej: hydroxysis ntawm hydroxy acids thiab cyclization los ua sclareolide
- Directional Cyclization: Cov ntiv nplhaib saib xyuas lub ntsej muag catalyzed los ntawm camfhor sulphor sulfonic acid
Ⅳ Kev hloov kho tshiab & cov khoom lag luam pom zoo
Xi'an app -}}}}}}}} Kev xa mus rau Twv Los Txog Kev Ua Haujlwm ntawm Shap Cog Cog Rau Tag Nrho Cov Kev Lag Luam Kev Lag Luam.
| Khoom | Cov Lus Qhia Tshwj Xeeb (Purity) | Daim ntawv thov |
| Sclareol | GC95% - gc98% | Cov txuj ci ua ntej rau cov khoom siv ntawm ambroxide |
| Sclareolide | GC95% - gc98% | Luam yeeb tsw cov khoom siv, tsw |
| Yog ambroxide | Gc99% | Khoom Kim Heev Cov naj hoom, Tshuaj pleev ib ce Tshuaj Pleev |
Appchem muab cov khoom siv ruaj khov thiab txhim khu kev qha rau cov qhua hauv ntiaj teb. Yog tias koj muaj cov kev xav tau uas cuam tshuam, thov hu rau peb. (email:sales@appchem.cn)