Hauv daim ntawv thov cov nroj tsuag rho tawm rau kev tswj ntshav qabzib, Coptis extract thiab iab melon extract tau txais kev saib xyuas tseem ceeb rau lawv cov teebmeem hypoglycemic. Txawm hais tias ob qho tib si rho tawm tau dav siv los tswj cov ntshav qab zib thiab muaj keeb kwm ntev ntawm kev siv thoob plaws ntau haiv neeg, lawv cov khoom siv, cov txheej txheem ntawm kev ua, thiab cov pov thawj kho mob pom qhov sib txawv. Rau cov kws tshaj lij kev muag khoom thiab kev tshawb fawb thiab kev tsim kho pab pawg, tau txais kev nkag siab zoo ntawm cov yam ntxwv ua haujlwm ntawm ob qho kev cog qoob loo no pab txhawb kev paub txog kev tshawb fawb thiab kev txiav txim siab lub hom phiaj thaum lub sij hawm tsim khoom.
Yuav Ua Li Cas Lawv Cov Khoom Uas Muaj Zog thiab Cov Mechanisms txawv?
Coptis chinensis extract yog muab los ntawm cov tshuaj suav tshuaj suav tshuaj Coptis chinensis, nrog berberine ua nws cov ntsiab lus tseem ceeb. Berberine yog ib tsob nroj alkaloid uas muaj cov tshuaj pharmacological dav; Kev tshawb fawb qhia tias nws pab txo qis cov ntshav qabzib los ntawm cov txheej txheem suav nrog inhibition ntawm cov piam thaj hauv siab, txhim kho insulin rhiab heev, thiab tswj cov roj metabolism. Raws li kev tshawb fawb xyoo 2021 hauv Phau Tsom Faj Txog Kev Kho Mob Endocrinology & Metabolism, berberine los ntawm Coptis chinensis siv nws cov teebmeem hypoglycaemic los ntawm kev hloov kho AMPK txoj hauv kev, txhim kho cov metabolism hauv fatty acid, thiab txo cov kab mob siab gluconeogenesis, qhia tshwj xeeb tshaj yog cov kev ua tau zoo ntawm cov neeg mob ntshav qab zib hom 2.
Bitter melon extract yog muab los ntawm Momordica charantia, uas nws cov khoom tseem ceeb muaj xws li momordicosides, iab melon protein, thiab flavonoids. Kev tshawb fawb qhia tias iab melon ua rau cov tshuaj insulin ua los ntawm cov khoom xws li momordicosides thiab iab melon protein, txhawb nqa cellular qabzib thiab txhim kho kev tso tawm insulin. Raws li kev tshawb fawb xyoo 2020 hauv Phau Ntawv Xov Xwm ntawm Ethnopharmacology, iab melon extract qhia tau hais tias muaj txiaj ntsig zoo hauv kev txhawb nqa cov piam thaj, txhawb kev ua haujlwm ntawm insulin, thiab txo qis cov ntshav qabzib, tshwj xeeb tshaj yog tsim nyog rau kev tswj cov ntshav qabzib.
Mechanistically, Coptis chinensis ua tiav nws cov teebmeem hypoglycemic feem ntau los ntawm AMPK kev tswj hwm thiab kev tswj hwm cov piam thaj hauv cov ntshav siab, thaum cov kua txiv hmab txiv ntoo qab zib tswj cov ntshav qab zib ntau ntxiv los ntawm insulin mimicry thiab cellular glucose uptake. Lawv cov txheej txheem hypoglycemic yog ua tiav tsis tau sib txawv: Coptis chinensis tsom mus rau kev hloov kho cov piam thaj hauv siab metabolism, thaum lub iab melon leans ntawm kev txhim kho cov tshuaj insulin.
Lawv Cov txiaj ntsig kho mob li cas piv rau kev tswj ntshav qab zib?
Coptis chinensis extract tau khaws cov kev tshawb fawb dav dav hauv kev siv tshuaj kho mob, tshwj xeeb yog hais txog kev kho mob thiab kev tswj glycemic ntawm hom 2 mob ntshav qab zib. Ib xyoo 2020 ob- qhov muag tsis pom kev sim luam tawm hauv Kev Kho Mob Ntshav Qab Zib pom tau tias berberine, ib feem ntawm Coptis chinensis extract, txo cov ntshav qabzib sai sai thiab txhim kho insulin rhiab heev hauv cov neeg mob ntshav qab zib hom 2. Nws cov txheej txheem ntawm kev ua tau zoo cuam tshuam nrog kev ua kom AMP-activated protein kinase (AMPK) txoj hauv kev. Berberine txoj kev tswj hwm cov txiaj ntsig ntawm cov piam thaj hauv cov metabolism ua rau nws ua tus neeg sawv cev zoo tshaj plaws ntawm hypoglycemic.
Hauv qhov sib piv, kev tshawb fawb soj ntsuam ntawm iab melon extract feem ntau tsom rau nws cov insulin-mimetic zog thiab kev kho mob ntawm hypoglycemia. Ib txoj kev tshawb fawb xyoo 2021 hauv Phytotherapy Kev Tshawb Fawb tau pom tias iab melon extract ua tau zoo nce qabzib thauj mus los (GLUT4) qhia, txhim kho cov tshuaj insulin, thiab pab txo qis cov ntshav qabzib tom qab. Bitter melon extract kuj tau pom cov txiaj ntsig zoo hauv kev tswj hwm tus kab mob prediabetes thiab mob ntshav qab zib.
Zuag qhia tag nrho, Coptis chinensis extract yog qhov zoo dua rau kev tswj hwm hyperglycemia thiab txhim kho insulin tsis kam, thaum iab melon extract nyiam tswj cov ntshav qabzib los ntawm kev txhim kho cov tshuaj insulin thiab nce cellular glycemia. Ob qho no nthuav tawm cov txiaj ntsig ntxiv hauv lawv txoj hauv kev rau kev txo cov piam thaj.
Dab tsi yog Bioavailability thiab Formulation Considerations?
Nyob rau hauv cov nqe lus ntawm kev tsim thiab bioavailability, berberine los ntawm Coptis chinensis nthuav tawm cov kev ua haujlwm lom neeg zoo tab sis kuj tsis tshua muaj bioavailability vim nws cov dej tsis zoo solubility thiab tsis muaj kev nqus hauv plab. Yog li ntawd, cov kws tshawb fawb tau ua haujlwm nrog cov txheej txheem nanotechnology thiab phospholipid complexes los txhim kho berberine's bioavailability. Raws li kev tshawb fawb xyoo 2022 hauv Phau Ntawv Xov Xwm ntawm Kev Tshawb Fawb Tshuaj, cov tswv yim no ua rau muaj txiaj ntsig zoo txhim kho berberine tus nqi nqus thiab bioavailability, yog li txhim kho nws cov tshuaj pharmacological.
Bitter melon extract qhia tau tias muaj bioavailability siab, nrog rau nws cov active Cheebtsam -xws li charantin thiab momordicin- sai sai exerting teebmeem nyob rau hauv lub cev. Bitter melon extract yog feem ntau ua tiav rau hauv cov hmoov, kua extract, los yog cov ntawv tshuaj ntsiav, nrog cov kua extracts ua tau zoo tshaj bioavailability. Hauv kev tsim cov khoom lag luam, iab melon extract tuaj yeem ua ke nrog lwm cov tshuaj tiv thaiv -glycaemic cov khoom xyaw (xws li cov tshuaj yej ntsuab los yog cov hauv paus dawb sedge) txhawm rau txhim kho kev ua tau zoo ntawm hypoglycemic tag nrho.
Dab tsi yog Kev Nyab Xeeb Profiles thiab Kev Tswj Xyuas Txheej Txheem Qhia?
Los ntawm kev pom kev nyab xeeb, Coptis chinensis extract feem ntau nthuav tawm qhov kev nyab xeeb zoo nyob rau ntau qhov xwm txheej. Kev tshawb fawb qhia tias Coptis chinensis nthuav tawm cov kev mob tshwm sim tsawg, txawm hais tias siab - kev tswj hwm koob tshuaj yuav ua rau mob plab tsis zoo xws li xeev siab lossis raws plab. Ib txoj kev tshawb fawb xyoo 2021 hauv Phau Tsom Faj ntawm Cov Khoom Siv Hauv Lub Ntiaj Teb tau qhia tias Coptis chinensis extract muaj kev nyab xeeb nyob rau hauv kev pom zoo ntau npaum li cas, txawm hais tias kev saib xyuas lub siab ua haujlwm tsis tu ncua yog pom zoo thaum siv sijhawm ntev.
Bitter melon extract yog feem ntau zoo- zam, txawm tias cov neeg tsawg yuav muaj kev tsis xis nyob hauv plab lossis hypoglycemia, tshwj xeeb tshaj yog thaum ua ke nrog lwm cov tshuaj hypoglycemic. Raws li kev tshawb fawb xyoo 2020 hauv Food and Chemical Toxicology, iab melon extract exhibits the low side effects; Txawm li cas los xij, kev tshawb fawb ntxiv yuav tsum tau tsim kom muaj kev nyab xeeb rau cov poj niam cev xeeb tub thiab lactating.
Yog li ntawd, ua tib zoo saib xyuas yuav tsum tau them rau ntau npaum li cas thiab qhov tsim nyog rau cov neeg tshwj xeeb thaum muab cov iab melon extract rau hauv cov qauv.
Cov ntsiab lus: Yuav Ua Li Cas Cov Neeg Yuav Khoom Coptis thiab Bitter Melon Extracts rau Kev Tswj Xyuas Ntshav Qab Zib?
Hauv cov ntsiab lus, ob qho tib si Coptis chinensis extract thiab iab melon extract muaj cov txheej txheem hypoglycemic sib txawv thiab tsim nyog rau kev tswj hwm ntshav qabzib sib txawv. Coptis chinensis extract yog tsim rau cov khoom lag luam txhawm rau txhim kho insulin tsis kam, tswj kev hyperglycemia, thiab hais txog ntshav qab zib- cuam tshuam txog cov teeb meem. Bitter melon extract, conversely, yog qhov zoo dua rau kev txhim kho insulin rhiab heev thiab txhawb nqa cov piam thaj, ua rau nws tsim nyog rau cov khoom lag luam tsom rau cov ntshav qab zib thiab kev tswj hwm hypoglycemia. Kev xaiv ntawm ob tuaj yeem coj los ntawm cov neeg siv khoom lub hom phiaj thiab kev ua haujlwm sib txawv ntawm cov khoom. Tej zaum lawv yuav txawm siv complementarily nyob rau hauv tib formulation los txhim kho tag nrho cov kev ua tau zoo.